| Entry |
|
|---|
| Name |
4-chlorobenzoyl-CoA dehalogenase |
|---|
| Class |
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
 |
|---|
| Sysname |
4-chlorobenzoyl CoA chlorohydrolase |
|---|
| Reaction(IUBMB) |
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride
[RN:R04101] |
|---|
| Reaction(KEGG) |
R04101;
(other) R08118
 |
|---|
| Substrate |
4-chlorobenzoyl-CoA [CPD:C06387];
H2O [CPD:C00001] |
|---|
| Product |
4-hydroxybenzoyl CoA;
chloride [CPD:C00698] |
|---|
| Comment |
Specific for dehalogenation at the 4-position. Can dehalogenate
substrates bearing fluorine, chlorine, bromine and iodine in the
4-position. This enzyme is part of the bacterial
2,4-dichlorobenzoate degradation pathway. |
|---|
| Pathway |
PATH: ec00364 Fluorobenzoate degradation
PATH: ec00623 2,4-Dichlorobenzoate degradation
PATH: ec01100 Metabolic pathways |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1610806]
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D.
Isolation and characterization of the three polypeptide components
of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
Biochemistry. 31 (1992) 5605-10.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7918379]
Crooks GP, Copley SD.
Purification and characterization of 4-chlorobenzoyl CoA
dehalogenase from Arthrobacter sp. strain 4-CB1.
Biochemistry. 33 (1994) 11645-9.
Arthrobacter sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.8.1.7
IUBMB Enzyme Nomenclature: 3.8.1.7
ExPASy - ENZYME nomenclature database: 3.8.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.7
BRENDA, the Enzyme Database: 3.8.1.7
CAS: 141583-18-8 |
|---|
