KEGG   ENZYME: 3.8.1.8Help
Entry
EC 3.8.1.8                  Enzyme                                 

Name
atrazine chlorohydrolase;
AtzA
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
atrazine chlorohydrolase
Reaction(IUBMB)
atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride [RN:R05558]
Reaction(KEGG)
R05558;
(other) R05569 R06968
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Substrate
atrazine [CPD:C06551];
H2O [CPD:C00001]
Product
4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine [CPD:C06552];
chloride [CPD:C00698]
Comment
Involved in the degradation of the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria.
History
EC 3.8.1.8 created 2000, modified 2011
Pathway
Atrazine degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K05394  
atrazine chlorohydrolase
Reference
1  [PMID:7574646]
  Authors
de Souza ML, Wackett LP, Boundy-Mills KL, Mandelbaum RT, Sadowsky MJ.
  Title
Cloning, characterization, and expression of a gene region from Pseudomonas sp. strain ADP involved in the dechlorination of atrazine.
  Journal
Appl. Environ. Microbiol. 61 (1995) 3373-8.
  Sequence
Reference
2  [PMID:8759853]
  Authors
de Souza ML, Sadowsky MJ, Wackett LP.
  Title
Atrazine chlorohydrolase from Pseudomonas sp. strain ADP: gene sequence, enzyme purification, and protein characterization.
  Journal
J. Bacteriol. 178 (1996) 4894-900.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
168680-16-8

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