KEGG   ENZYME: 3.8.1.9Help
Entry
EC 3.8.1.9                  Enzyme                                 

Name
(R)-2-haloacid dehalogenase;
2-haloalkanoic acid dehalogenase[ambiguous];
2-haloalkanoid acid halidohydrolase[ambiguous];
D-2-haloacid dehalogenase;
D-DEX
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
(R)-2-haloacid halidohydrolase
Reaction(IUBMB)
(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide [RN:R07308]
Reaction(KEGG)
Substrate
(R)-2-haloacid [CPD:C15564];
H2O [CPD:C00001]
Product
(S)-2-hydroxyacid [CPD:C15565];
halide [CPD:C00462]
Comment
Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]
History
EC 3.8.1.9 created 2003
Reference
1  [PMID:2380688]
  Authors
Smith JM, Harrison K, Colby J.
  Title
Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23.
  Journal
J. Gen. Microbiol. 136 (1990) 881-6.
Reference
2
  Authors
Leigh, J.A., Skinner, A.J. and Cooper, R.A.
  Title
Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species.
  Journal
FEMS Microbiol. Lett. 49 (1988) 353-356.
Reference
3
  Authors
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
  Title
Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
  Journal
Pure Appl. Chem. 68 (1996) 2097-2103.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
119345-29-8

DBGET integrated database retrieval system