KEGG   ENZYME: 4.1.1.100Help
Entry
EC 4.1.1.100                Enzyme                                 

Name
prephenate decarboxylase;
BacA;
AerD;
SalX;
non-aromatizing prephenate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
prephenate carboxy-lyase (3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate-forming)
Reaction(IUBMB)
prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 [RN:R10934]
Reaction(KEGG)
Substrate
prephenate [CPD:C00254]
Product
3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate [CPD:C20953];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate.
History
EC 4.1.1.100 created 2015
Pathway
Biosynthesis of antibiotics
Orthology
K19546  
bacA; prephenate decarboxylase
Genes
VGA: 
LPA: 
RAC: 
MAQU: 
BSU: 
BSU37740(bacA)
BSR: 
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSO: 
BSN: 
BSQ: 
BSX: 
C663_3679(bacA)
BSP: 
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
RBAU_3631(bacA)
BAMN: 
BASU_3407(bacA)
BAMB: 
BAMT: 
BAMY: 
BMP: 
BAO: 
BAMF_3607(bacA)
BAZ: 
BQL: 
LL3_03918(bacA)
BXH: 
BQY: 
MUS_4152(bacA)
BAMI: 
BAMC: 
BAMF: 
BVM: 
BPU: 
BPUM: 
BPUS: 
BJS: 
BACW: 
BACP: 
BACB: 
BACY: 
BACL: 
BALM: 
BGI: 
PXL: 
STRM: 
STRT: 
SGS: 
SRO: 
MAR: 
MPK: 
MPRO: 
 » show all
Taxonomy
Reference
1  [PMID:20052993]
  Authors
Mahlstedt SA, Walsh CT
  Title
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
  Journal
Biochemistry. 49 (2010) 912-23.
Reference
2  [PMID:20863139]
  Authors
Mahlstedt S, Fielding EN, Moore BS, Walsh CT
  Title
Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.
  Journal
Biochemistry. 49 (2010) 9021-3.
Reference
3  [PMID:22483065]
  Authors
Parker JB, Walsh CT
  Title
Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis.
  Journal
Biochemistry. 51 (2012) 3241-51.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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