KEGG   ENZYME: 4.1.1.53Help
Entry
EC 4.1.1.53                 Enzyme                                 

Name
phenylalanine decarboxylase;
L-phenylalanine decarboxylase;
aromatic L-amino acid decarboxylase;
L-phenylalanine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-phenylalanine carboxy-lyase (phenylethylamine-forming)
Reaction(IUBMB)
L-phenylalanine = phenylethylamine + CO2 [RN:R00699]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079]
Product
phenylethylamine [CPD:C05332];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also acts on tyrosine and other aromatic amino acids.
History
EC 4.1.1.53 created 1972
Pathway
Phenylalanine metabolism
Reference
1  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J. Biol. Chem. 237 (1962) 89-93.
  Organism
Rattus norvegicus, Canis familiaris, Cavia porcellus
Reference
2  [PMID:6034195]
  Authors
Schulz AR, Oliner L.
  Title
The possible role of thyroid aromatic amino acid decarboxylase in thyroxine biosynthesis.
  Journal
Life. Sci. 6 (1967) 873-80.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-72-3

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