KEGG   ENZYME: 4.1.1.75Help
Entry
EC 4.1.1.75                 Enzyme                                 

Name
5-guanidino-2-oxopentanoate decarboxylase;
alpha-ketoarginine decarboxylase;
2-oxo-5-guanidinopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)
Reaction(IUBMB)
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 [RN:R03178]
Reaction(KEGG)
Substrate
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
4-guanidinobutanal [CPD:C02647];
CO2 [CPD:C00011]
Comment
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
History
EC 4.1.1.75 created 1999
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K12253  
5-guanidino-2-oxopentanoate decarboxylase
Genes
PAE: 
PA4977(aruI)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PRE: 
PPF: 
PPG: 
PPT: 
PPB: 
PPI: 
PPX: 
PPUH: 
PPUT: 
PPUN: 
PPUD: 
PMON: 
PMOT: 
PPJ: 
PFL: 
PPRC: 
PPRO: 
PPC_2761(aruI)
PFW: 
PFF: 
PMAN: 
PTV: 
PPUU: 
PDR: 
PSK: 
PKC: 
PCZ: 
PALK: 
PSEM: 
PSOS: 
SHZ: 
RLI: 
OAT: 
OAR: 
OTM: 
OSB_09640(aruI)
PTP: 
MOX: 
 » show all
Taxonomy
Reference
1  [PMID:237915]
  Authors
Vanderbilt AS, Gaby NS, Rodwell VW.
  Title
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida.
  Journal
J. Biol. Chem. 250 (1975) 5322-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56831-67-5

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