KEGG   ENZYME: 4.1.1.78Help
Entry
EC 4.1.1.78                 Enzyme                                 

Name
acetylenedicarboxylate decarboxylase;
acetylenedicarboxylate hydratase;
acetylenedicarboxylate hydrase;
acetylenedicarboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
acetylenedicarboxylate carboxy-lyase (pyruvate-forming)
Reaction(IUBMB)
acetylenedicarboxylate + H2O = pyruvate + CO2 [RN:R00218]
Reaction(KEGG)
R00218;
(other) R04177
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Substrate
acetylenedicarboxylate [CPD:C03248];
H2O [CPD:C00001]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011]
Comment
The mechanism appears to involve hydration of the acetylene and decarboxylation of the oxaloacetic acid formed, although free oxaloacetate is not an intermediate. It is thus analogous to EC 4.2.1.27 (acetylenecarboxylate hydratase) in its mechanism.
History
EC 4.1.1.78 created 1978 as EC 4.2.1.72, transferred 2000 to EC 4.1.1.78
Pathway
Pyruvate metabolism
Reference
1  [PMID:13575441]
  Authors
YAMADA EW, JAKOBY WB.
  Title
Enzymatic utilization of acetylenic compounds. I. An enzyme converting acetylenedicarboxylic acid to pyruvate.
  Journal
J. Biol. Chem. 233 (1958) 706-11.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72561-10-5

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