| Entry |
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| Name |
threonine-phosphate decarboxylase;
L-threonine-O-3-phosphate decarboxylase;
CobD;
L-threonine-O-3-phosphate carboxy-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
L-threonine-O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]
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| Reaction(IUBMB) |
L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2 [RN: R06530]
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| Reaction(KEGG) |
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| Substrate |
L-threonine O-3-phosphate [CPD: C12147]
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| Product |
(R)-1-aminopropan-2-yl phosphate [CPD: C04122];
CO2 [CPD: C00011]
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| Comment |
A pyridoxal-phosphate protein. This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide-phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
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| Pathway |
| Porphyrin and chlorophyll metabolism |
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| Orthology |
| threonine-phosphate decarboxylase |
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| Genes |
EBT: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEL: | | SET: | | SENJ: | | SES: | | YEN: | | YEP: | | YEY: | | PLU: | | PAY: | | ESC: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | EIC: | | ETR: | | ETD: | | ETC: | | XBO: | | XNE: | | MMK: | | ROR: | | EBF: | | MAH: | | HEL: | | TAU: | | SUA: | | SKU: | | ANT: | | ARC: | | SBA: | | GSK: | | GME: | | GUR: | | GBM: | | GEO: | | GEM: | | GEB: | | PPD: | | DVM: | | DDE: | | DAK: | | DPR: | | DAL: | | DAT: | | DTO: | | DAO: | | SFU: | | DBR: | | HMR: | | DIN: | | BHA: | | BPF: | | BMQ: | | BMD: | | BMH: | | BACI: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMG: | | LMS: | | LMJ: | | LMQ: | | LML: | | LMP: | | LMW: | | LMX: | | LMZ: | | LMON: | | LMOC: | | LMOS: | | LMOO: | | LMOY: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LMOE: | | LMOB: | | LIN: | | LWE: | | LSG: | | LIV: | | LSP: | | PPO: | | PTA: | | BTS: | | SIV: | | LRU: | | PCE: | | AUR: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CTC: | | CNO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBB: | | CBI: | | CBN: | | CBF: | | CBM: | | CBJ: | | CKL: | | CKR: | | CPY: | | CLJ: | | CSO: | | CLS: | | CAD: | | CSR: | | CPAS: | | CDF: | | CDC: | | CDL: | | CDG: | | CST: | | FAA: | | AOE: | | STH: | | SLP: | | DDH: | | DDL: | | DRM: | | DAE: | | DCA: | | DKU: | | DRU: | | PTH: | | DAU: | | TJR: | | SGY: | | DOR: | | DAI: | | DMI: | | HMO: | | FMA: | | ERE: | | ERT: | | ERA: | | ELM: | | ESU: | | AWO: | | BFI: | | CLE: | | RHO: | | RIX: | | RIM: | | COO: | | RUM: | | ROB: | | RTO: | | FPR: | | FPA: | | SAY: | | SAP: | | BPRL: | | TTE: | | TEX: | | THX: | | TPD: | | TIT: | | TMT: | | TBO: | | TWI: | | TEP: | | TAE: | | MTA: | | ADG: | | TPZ: | | TOC: | | TTM: | | TTO: | | TXY: | | TSH: | | MAS: | | NTH: | | HPK: | | AAR: | | HHL: | | VPR: | | SSG: | | SRI: | | MED: | | MHG: | | RXY: | | AYM: | | CCU: | | SHI: | | EYY: | | TDE: | | TPI: | | SSM: | | GMA: | | CTM: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | PPN: | | OSP: | | TFO: | | PRU: | | CPI: | | DFE: | | FCO: | | FNU: | | LBA: | | STR: | | IPO: | | IPA: | | SACI: | | TAI: | | TLI: | | SBR: | | CPC: | | CCH: | | CPH: | | CPB: | | CLI: | | PVI: | | PPH: | | PAA: | | CTS: | | DEB: | | RCA: | | CAG: | | CHL: | | TYE: | | NDE: | | LFC: | | LFI: | | DDF: | | DAP: | | CNI: | | TID: | | MBA: | | MMAZ: | | MBU: | | MMH: | | MEV: | | MZH: | | MPY: | | MHZ: | | MHI: | | MBG: | | MPD: | | MEZ: | | RCI: | | FPL: | | HSL: | | HHI: | | HWA: | | HWC: | | NPH: | | NMO: | | HMU: | | HTU: | | NMG: | | HVO: | | HME: | | HJE: | | HBO: | | HXA: | | NAT: | | NPE: | | NGE: | | HRU: | | NOU: | | TAR: | | MAX: | | IAG: | | PFM: | | VDI: | | VMO: | | ASC: | | CLG: | | FFO: | | NMR: | | NIR: | | NKR: | | CSY: | | NGA: | | HAH: | |
» show all
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| Reference |
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| Authors |
Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I. |
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| Title |
Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica. |
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| Journal |
Biochemistry. 41 (2002) 4798-808. |
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| Organism |
Salmonella enterica [GN: spq] |
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| Sequence |
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| Reference |
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| Authors |
Brushaber KR, O'Toole GA, Escalante-Semerena JC |
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| Title |
CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2. |
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| Journal |
J. Biol. Chem. 273 (1998) 2684-91. |
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| Reference |
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| Authors |
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC. |
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| Title |
The biosynthesis of adenosylcobalamin (vitamin B12). |
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| Journal |
Nat. Prod. Rep. 19 (2002) 390-412. |
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| Organism |
Salmonella enterica, Pseudomonas denitrificans |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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