KEGG   ENZYME: 4.1.1.86Help
Entry
EC 4.1.1.86                 Enzyme                                 

Name
diaminobutyrate decarboxylase;
DABA DC;
L-2,4-diaminobutyrate decarboxylase;
L-2,4-diaminobutanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming)
Reaction(IUBMB)
L-2,4-diaminobutanoate = propane-1,3-diamine + CO2 [RN:R07650]
Reaction(KEGG)
Substrate
L-2,4-diaminobutanoate [CPD:C03283]
Product
propane-1,3-diamine [CPD:C00986];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein that requires a divalent cation for activity [1]. N4-Acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates. Found in the proteobacteria Haemophilus influenzae and Acinetobacter baumannii. In the latter, this enzyme is cotranscribed with the dat gene that encodes EC 2.6.1.76, diaminobutyrate---2-oxoglutarate transaminase, which can supply the substrate for this enzyme.
History
EC 4.1.1.86 created 2006
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K13745  L-2,4-diaminobutyrate decarboxylase
Genes
ENT: Ent638_2714
ENC: ECL_03422
ENO: ECENHK_14865
EEC: EcWSU1_03023(ddc)
ENL: A3UG_15385
ECLG: EC036_29880
ECLE: ECNIH2_15405
ECLN: ECNIH4_07785
ECLI: ECNIH5_14355
ECLX: LI66_14745
ECLY: LI62_16255
ECLZ: LI64_14190
KPN: KPN_01803
KPU: KP1_2853
KPP: A79E_2433
KPT: VK055_0686(ddc)
KPE: KPK_2552(ddc)
KPR: KPR_2427(ddc)
KPJ: N559_2497
KPX: PMK1_04142(ddc)
KPNU: LI86_12395
KPNK: BN49_2900(ddc)
KVA: Kvar_2498
KOX: KOX_20315
KOE: A225_2930
EAE: EAE_19525
EAR: CCG29980
EBF: D782_2172
YPE: YPO1529
YPK: y2641(ysuJ)
YPA: YPA_0823
YPN: YPN_2451
YPM: YP_1418(ysuJ)
YPZ: YPZ3_1394
YPD: YPD4_1360
YPX: YPD8_1588
YPH: YPC_2623
YPW: CH59_309
YPJ: CH55_1009
YPV: BZ15_2023
YPL: CH46_3597
YPS: YPTB1541
YPO: BZ17_974
YPY: YPK_2547
YPB: YPTS_1651
YPQ: DJ40_671
YPU: BZ21_879
YPR: BZ20_423
YPC: BZ23_1158
YPF: BZ19_979
YAL: AT01_1815
SPE: Spro_2418
SRL: SOD_c22580(ddc1)
SPLY: Q5A_012645(ddc_1)
SMAF: D781_2290
SMAR: SM39_1864(ddc)
SMAC: SMDB11_1682(ddc)
SERF: L085_16575
ECA: ECA2244(ddc)
PATR: EV46_10775
PATO: GZ59_23170(ddc)
PCT: PC1_2059
PEC: W5S_2298
ETA: ETA_04470(ddc) ETA_30280
EPY: EpC_04510(ddc) EpC_32410
EPR: EPYR_00474(ddc) EPYR_03489(dfoJ)
EAM: EAMY_0466(ddc) EAMY_3238(dfoJ)
EAY: EAM_0361 EAM_2959(ddc)
EBI: EbC_22090(ddc) EbC_24990
EGE: EM595_p0459(ddc)
PAM: PANA_0635(ddc) PANA_4109(ddc)
PAJ: PAJ_3770(ddc) PAJ_p0181(ddc)
PLU: plu4628
XNE: XNC1_1305
XNM: XNC2_1272
XDO: XDD1_1243
HIN: HI0946.1
HIT: NTHI1119(ddc)
HIU: HIB_10850
HIE: R2846_1363(ddc)
HIZ: R2866_1435(ddc)
HIK: HifGL_000574(ddc)
HIA: H733_1489
HIW: NTHI477_00761(ddc)
HIC: NTHIC486_00027(ddc)
HIX: NTHI723_00666(ddc)
HDU: HD_0726(ddc)
HAP: HAPS_1296(ddc)
HPAZ: K756_00180
HPAS: JL26_10890
HPAK: JT17_08690
HSO: HS_0927(ddc)
HSM: HSM_1405
MSU: MS0827(gadB)
MHT: D648_3380
MHAT: B824_23330
MHX: MHH_c08840(ddc)
MHAE: F382_09565
MHAM: J450_08500
MHAO: J451_09785
MHAL: N220_01655
MHAQ: WC39_12195
MHAY: VK67_12200
MVI: X808_2200
MVG: X874_2300
APL: APL_1975(ddc)
APJ: APJL_2024(ddc)
APA: APP7_2063(ddc)
ASU: Asuc_1496
BTO: WQG_1970
BTRE: F542_19970
BTRH: F543_21880
BTRA: F544_1530
VSP: VS_1947
PALI: A3K91_1221
ACB: A1S_2453
ABM: ABSDF1093.4(ddc)
ABY: ABAYE1027(ddc)
ABN: AB57_2880
ABX: ABK1_2782
ABH: M3Q_2964
ABAD: ABD1_24400(ddc)
ABAZ: P795_4690
ABAU: IX87_08925
ABAA: IX88_15460
ACC: BDGL_001922(ddc)
ACI: ACIAD1211(ddc)
ASJ: AsACE_CH00995(ddc)
MCT: MCR_0362
MCS: DR90_1539(ddc)
MCAT: MC25239_00382(ddc)
PSM: PSM_B0022
MBS: MRBBS_3775(ddc)
PIN: Ping_2288
FPH: Fphi_0925
FPT: BZ13_1106
FPI: BF30_1154
FPM: LA56_1253
FPX: KU46_403
FPZ: LA55_1973
FPJ: LA02_328
FNA: OOM_0523
NTT: TAO_0296
CSA: Csal_1055
AAV: Aave_4221
AAA: Acav_4094
MFA: Mfla_2033
MEP: MPQ_0725(gadB)
MBAC: BN1209_1178(gadB)
MXA: MXAN_6783
CCX: COCOR_07385(ddc)
SCL: sce6892
SME: SMa2402(rhbB)
SMEL: SM2011_a2402(rhbB)
RSU: NHU_02005
BLI: BL01335
BLD: BLi01184(rhbB)
BLH: BaLi_c13160(rhbB)
BHA: BH2623(ddc)
BPU: BPUM_1020
BPUM: BW16_05845
BPUS: UP12_05455
BMQ: BMQ_4068
BMD: BMD_4053
BMEG: BG04_986
BACW: QR42_05290
BGY: BGLY_1215
PMW: B2K_33600
SCG: SCI_1172(gadA)
SCON: SCRE_1113(gadA)
SCOS: SCR2_1113(gadA)
MABB: MASS_1778
MABO: NF82_08525
MCHE: BB28_09160
MSTE: MSTE_01685
CCJ: UL81_01880(desA)
GOR: KTR9_0499
SCO: SCO2017(SC7H2.31c) SCO2782(SCC105.13)
SMA: SAVERM_5272(sidD)
SCT: SCAT_1144 SCAT_p1223(rhbB)
SALS: SLNWT_5881
STRP: F750_1863 F750_2608(desA)
SLD: T261_6372
STRM: M444_13345
SAMB: SAM23877_2103(rhbB) SAM23877_2817(desA)
SRW: TUE45_02531(ddc_2) TUE45_03397(ddc_3)
SLE: sle_44580(desA) sle_51220(sle_51220)
SRN: A4G23_01834(ddc_1) A4G23_04772(ddc_2)
SALF: SMD44_02200(ddc) SMD44_02201(ddc) SMD44_03080(ddc)
SLX: SLAV_23925(ddc1) SLAV_27505(ddc3)
KSK: KSE_62530
CMI: CMM_2095
CMS: CMS1133
CMC: CMN_02059
ART: Arth_0285
ARR: ARUE_c02640(rhbB)
ARX: ARZXY2_3650(ddc)
AAU: AAur_0266
ACH: Achl_0512
LMOI: VV02_14840
XCE: Xcel_1803
IDO: I598_1669(ddc)
CFL: Cfla_0196
CFI: Celf_3060
KFL: Kfla_3181
NDA: Ndas_1074
SRO: Sros_1177
FAL: FRAAL6422
AMD: AMED_2692
AMN: RAM_13685
AMM: AMES_2664
AMZ: B737_2665
ACTI: UA75_12115
ACAD: UA74_12030
AHG: AHOG_11340(ddc1)
MIL: ML5_5796
AMS: AMIS_67520(sidD)
ASE: ACPL_6999(sidD)
ACTS: ACWT_6868
TBI: Tbis_3459
GVI: gll2222
ANA: all0395
AVA: Ava_2838
CTHE: Chro_4470
PLS: VT03_07720(ddc)
GAU: GAU_3583
GBA: J421_0892
CPI: Cpin_2835
FLN: FLA_1333
CHU: CHU_0590(iscS)
FAE: FAES_0048(iscS)
FJO: Fjoh_3171
MARM: YQ22_00530
DDO: I597_0451(ddc)
ZGA: ZOBELLIA_4235(ddc)
MLT: VC82_95
EAO: BD94_2298
ELB: VO54_00401(ddc)
TMAR: MARIT_0169(tbsA)
HAL: VNG_6211G(bdb)
HSL: OE_5095F(bdb)
HMU: Hmuk_3330
HVO: HVO_B0045(bdb)
HME: HFX_5044
HTU: Htur_0214
NAT: NJ7G_0331
MARC: AR505_1464
 » show all
Taxonomy
Reference
1  [PMID:1512577]
  Authors
Yamamoto S, Tsuzaki Y, Tougou K, Shinoda S.
  Title
Purification and characterization of L-2,4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus.
  Journal
J. Gen. Microbiol. 138 (1992) 1461-5.
Reference
2  [PMID:7813892]
  Authors
Ikai H, Yamamoto S.
  Title
Cloning and expression in Escherichia coli of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii.
  Journal
FEMS. Microbiol. Lett. 124 (1994) 225-8.
Reference
3  [PMID:9260954]
  Authors
Ikai H, Yamamoto S.
  Title
Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii.
  Journal
J. Bacteriol. 179 (1997) 5118-25.
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.86
IUBMB Enzyme Nomenclature: 4.1.1.86
ExPASy - ENZYME nomenclature database: 4.1.1.86
BRENDA, the Enzyme Database: 4.1.1.86

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