KEGG   ENZYME: 4.1.1.91Help
Entry
EC 4.1.1.91                 Enzyme                                 

Name
salicylate decarboxylase;
salicylic acid decarboxylase;
Scd
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
salicylate carboxy-lyase
Reaction(IUBMB)
salicylate = phenol + CO2 [RN:R09539]
Reaction(KEGG)
Substrate
salicylate [CPD:C00805]
Product
phenol [CPD:C00146];
CO2 [CPD:C00011]
Comment
In the reverse direction the enzyme catalyses the regioselective carboxylation of phenol into stoichiometric amounts of salicylate. The enzyme also catalyses the reversible decarboxylation of 2,4-dihydroxybenzoate, 2,6-dihydroxybenzoate, 2,3-dihydroxybenzoate and 4-aminosalicylate [1].
History
EC 4.1.1.91 created 2011
Reference
1  [PMID:20188702]
  Authors
Kirimura K, Gunji H, Wakayama R, Hattori T, Ishii Y
  Title
Enzymatic Kolbe-Schmitt reaction to form salicylic acid from phenol: enzymatic characterization and gene identification of a novel enzyme, Trichosporon moniliiforme salicylic acid decarboxylase.
  Journal
Biochem. Biophys. Res. Commun. 394 (2010) 279-84.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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