KEGG   ENZYME: 4.1.1.93Help
Entry
EC 4.1.1.93                 Enzyme                                 

Name
pyrrole-2-carboxylate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
pyrrole-2-carboxylate carboxy-lyase
Reaction(IUBMB)
(1) pyrrole-2-carboxylate = pyrrole + CO2 [RN:R09794];
(2) pyrrole-2-carboxylate + H2O = pyrrole + HCO3- [RN:R09795]
Reaction(KEGG)
Substrate
pyrrole-2-carboxylate [CPD:C05942];
H2O [CPD:C00001]
Product
pyrrole [CPD:C19907];
CO2 [CPD:C00011];
HCO3- [CPD:C00288]
Comment
The enzyme catalyses both the carboxylation and decarboxylation reactions. However, while bicarbonate is the preferred substrate for the carboxylation reaction, decarboxylation produces carbon dioxide. The enzyme is activated by carboxylic acids.
History
EC 4.1.1.93 created 2011
Reference
1  [PMID:9826198]
  Authors
Wieser M, Fujii N, Yoshida T, Nagasawa T
  Title
Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910.
  Journal
Eur. J. Biochem. 257 (1998) 495-9.
Reference
2  [PMID:9654100]
  Authors
Omura H, Wieser M, Nagasawa T
  Title
Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme.
  Journal
Eur. J. Biochem. 253 (1998) 480-4.
Reference
3
  Authors
Wieser, M., Yoshida, T. and Nagasawa, T.
  Title
Microbial synthesis of pyrrole-2-carboxylate by Bacillus megaterium PYR2910.
  Journal
Tetrahedron Lett. 39 (1998) 4309-4310.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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