KEGG   ENZYME: 4.1.1.95Help
Entry
EC 4.1.1.95                 Enzyme                                 

Name
L-glutamyl-[BtrI acyl-carrier protein] decarboxylase;
btrK (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-glutamyl-[BtrI acyl-carrier protein] carboxy-lyase
Reaction(IUBMB)
L-glutamyl-[BtrI acyl-carrier protein] = 4-amino butanoyl-[BtrI acyl-carrier protein] + CO2 [RN:R08907]
Reaction(KEGG)
Substrate
L-glutamyl-[BtrI acyl-carrier protein]
Product
4-amino butanoyl-[BtrI acyl-carrier protein];
CO2 [CPD:C00011]
Comment
Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.
History
EC 4.1.1.95 created 2012
Pathway
Neomycin, kanamycin and gentamicin biosynthesis
Biosynthesis of antibiotics
Orthology
K13560  
L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
Reference
1  [PMID:15975512]
  Authors
Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB
  Title
Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.
  Journal
Chem. Biol. 12 (2005) 665-75.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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