KEGG   ENZYME: 4.1.1.99Help
Entry
EC 4.1.1.99                 Enzyme                                 

Name
phosphomevalonate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
ATP:phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Reaction(IUBMB)
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]
Comment
The enzyme is part of the mevalonate pathway in archaea.
History
EC 4.1.1.99 created 2014
Pathway
Terpenoid backbone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K17942  
phosphomevalonate decarboxylase
Genes
HAL: 
HSL: 
OE_1893F(mvaD)
HMA: 
HHI: 
HHN: 
HAB: 
NPH: 
NP_1580A(mvaD)
NMO: 
Nmlp_1993(mvaD)
HUT: 
HTI: 
HMU: 
HJE: 
HWA: 
HQ_1525A(mvaD)
HWC: 
Hqrw_1624(mvaD)
HLA: 
HVO: 
HVO_1412(mvaD)
HME: 
HBO: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:24375100]
  Authors
Vannice JC, Skaff DA, Keightley A, Addo J, Wyckoff GJ, Miziorko HM.
  Title
Identification in Haloferax volcanii of Phosphomevalonate Decarboxylase and Isopentenyl Phosphate Kinase as Catalysts of the Terminal Enzymatic Reactions in  an Archaeal Alternate Mevalonate Pathway.
  Journal
J. Bacteriol.  (2013) .
  Sequence
[hvo:HVO_1412]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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