KEGG   ENZYME: 4.1.2.10Help
Entry
EC 4.1.2.10                 Enzyme                                 

Name
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(R)-mandelonitrile = cyanide + benzaldehyde [RN:R01767]
Reaction(KEGG)
R01767;
(other) R01409 R02811
Show
Substrate
(R)-mandelonitrile [CPD:C00561]
Product
cyanide [CPD:C00177];
benzaldehyde [CPD:C00261]
Comment
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
History
EC 4.1.2.10 created 1961, modified 1999, modified 2011
Pathway
Cyanoamino acid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K08248  
mandelonitrile lyase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os06t0656000-00(Os06g0656000)
OBR: 
BDI: 
SBI: 
SORBI_10g026110(SORBIDRAFT_10g026110)
ZMA: 
SITA: 
ATR: 
s00025p00245990(AMTR_s00025p00245990) s00028p00205610(AMTR_s00028p00205610) s00028p00206870(AMTR_s00028p00206870) s00028p00206910(AMTR_s00028p00206910) s00028p00208270(AMTR_s00028p00208270)
 » show all
Taxonomy
Reference
1  [PMID:18540101]
  Authors
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A
  Title
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat).
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 1513-22.
Reference
2
  Authors
Lin, G., Han, S. and Li, Z.
  Title
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium.
  Journal
Tetrahedron 55 (1999) 3531-3540.
Reference
3
  Authors
de Gonzalo, G., Brieva, R. and Gotor, V.
  Title
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals.
  Journal
J. Mol. Catal. B 19-20 (2002) 223-230.
Reference
4
  Authors
Ueatrongchit, T., Tamura, K., Ohmiya, T., H-Kittikun, A. and Asano, Y.
  Title
Hydroxynitrile lyase from Passiflora edulis. Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile.
  Journal
Enzyme Microb. Technol. 46 (2010) 456-465.
Reference
5  [PMID:17907254]
  Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
  Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
  Journal
Angew. Chem. Int. Ed. Engl. 46 (2007) 8679-81.
  Organism
Arabidopsis thaliana
  Sequence
[up:Q9LFT6]
Reference
6  [PMID:19433222]
  Authors
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M
  Title
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
  Journal
J. Biotechnol. 141 (2009) 166-73.
  Organism
Arabidopsis thaliana
  Sequence
[up:Q9LFT6]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-43-5

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