KEGG   ENZYME: 4.1.2.10Help
Entry
EC 4.1.2.10                 Enzyme                                 

Name
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(R)-mandelonitrile = cyanide + benzaldehyde [RN:R01767]
Reaction(KEGG)
R01767;
(other) R01409 R02811
Show
Substrate
(R)-mandelonitrile [CPD:C00561]
Product
cyanide [CPD:C00177];
benzaldehyde [CPD:C00261]
Comment
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
History
EC 4.1.2.10 created 1961, modified 1999, modified 2011
Pathway
Cyanoamino acid metabolism
Biosynthesis of secondary metabolites
Orthology
K08248  
mandelonitrile lyase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
EGR: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
BVG: 
OSA: 
DOSA: 
Os06t0656000-00(Os06g0656000)
OBR: 
BDI: 
SBI: 
SORBI_10g026110(SORBIDRAFT_10g026110)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00025p00245990(AMTR_s00025p00245990) s00028p00205610(AMTR_s00028p00205610) s00028p00206870(AMTR_s00028p00206870) s00028p00206910(AMTR_s00028p00206910) s00028p00208270(AMTR_s00028p00208270)
SMO: 
 » show all
Taxonomy
Reference
1  [PMID:18540101]
  Authors
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A
  Title
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat).
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 1513-22.
Reference
2
  Authors
Lin, G., Han, S. and Li, Z.
  Title
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium.
  Journal
Tetrahedron 55 (1999) 3531-3540.
Reference
3
  Authors
de Gonzalo, G., Brieva, R. and Gotor, V.
  Title
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals.
  Journal
J. Mol. Catal. B 19-20 (2002) 223-230.
Reference
4
  Authors
Ueatrongchit, T., Tamura, K., Ohmiya, T., H-Kittikun, A. and Asano, Y.
  Title
Hydroxynitrile lyase from Passiflora edulis. Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile.
  Journal
Enzyme Microb. Technol. 46 (2010) 456-465.
Reference
5  [PMID:17907254]
  Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
  Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
  Journal
Angew. Chem. Int. Ed. Engl. 46 (2007) 8679-81.
  Sequence
[up:Q9LFT6]
Reference
6  [PMID:19433222]
  Authors
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M
  Title
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
  Journal
J. Biotechnol. 141 (2009) 166-73.
  Sequence
[up:Q9LFT6]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-43-5

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