KEGG   ENZYME: 4.1.2.10Help
Entry
EC 4.1.2.10                 Enzyme                                 

Name
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(R)-mandelonitrile = cyanide + benzaldehyde [RN:R01767]
Reaction(KEGG)
R01767;
(other) R01409 R02811
Show
Substrate
(R)-mandelonitrile [CPD:C00561]
Product
cyanide [CPD:C00177];
benzaldehyde [CPD:C00261]
Comment
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
History
EC 4.1.2.10 created 1961, modified 1999, modified 2011
Pathway
ec00460  Cyanoamino acid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K08248  (R)-mandelonitrile lyase
K20802  (R)-mandelonitrile lyase
Genes
ATH: AT1G73050 AT5G10300(MES5)
ALY: ARALYDRAFT_476435 ARALYDRAFT_487858
CRB: 17882602 17894548
CSAT: 104701992 104712914 104751159
EUS: EUTSA_v10014451mg EUTSA_v10018360mg
BRP: 103831793 103846819 103852822
BNA: 106354249 106372481 106378088 106379433 106381275 106404872
BOE: 106299217 106327722
THJ: 104798892 104812207
CPAP: 110824699 110824820
CIT: 102626291
TCC: 18595196
GRA: 105767552
DZI: 111280688
EGR: 104423258
GMX: 100820069
VRA: 106773780
VAR: 108320669
CCAJ: 109808261
CAM: 101508164
ADU: 107482361
AIP: 107635832
LJA: Lj3g3v2040180.1(Lj3g3v2040180.1)
LANG: 109356592
RCU: 107260750
JCU: 105643749
HBR: 110655857
VVI: 100254058
SLY: 101250204
SPEN: 107014093
SOT: 102580581
CANN: 107865788
NSY: 104246964
NTO: 104107041
SIND: 105157899
OEU: 111401494
BVG: 104901404
SOE: 110785208
NNU: 104599090
OSA: 9266710
DOSA: Os06t0656000-00(Os06g0656000)
OBR: 102719124
BDI: 100822804
ATS: 109783110(LOC109783110)
SBI: 8069366
ZMA: 100382914
SITA: 101763110
PDA: 103715972
EGU: 105039402
MUS: 103977401
DCT: 110096808
 » show all
Taxonomy
Reference
1  [PMID:18540101]
  Authors
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A
  Title
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat).
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 1513-22.
Reference
2
  Authors
Lin, G., Han, S. and Li, Z.
  Title
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium.
  Journal
Tetrahedron 55 (1999) 3531-3540.
Reference
3
  Authors
de Gonzalo, G., Brieva, R. and Gotor, V.
  Title
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals.
  Journal
J. Mol. Catal. B 19-20 (2002) 223-230.
Reference
4
  Authors
Ueatrongchit, T., Tamura, K., Ohmiya, T., H-Kittikun, A. and Asano, Y.
  Title
Hydroxynitrile lyase from Passiflora edulis. Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile.
  Journal
Enzyme Microb. Technol. 46 (2010) 456-465.
Reference
5  [PMID:17907254]
  Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
  Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
  Journal
Angew. Chem. Int. Ed. Engl. 46 (2007) 8679-81.
  Sequence
[ath:AT5G10300]
Reference
6  [PMID:19433222]
  Authors
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M
  Title
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
  Journal
J. Biotechnol. 141 (2009) 166-73.
  Sequence
[ath:AT5G10300]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.10
IUBMB Enzyme Nomenclature: 4.1.2.10
ExPASy - ENZYME nomenclature database: 4.1.2.10
BRENDA, the Enzyme Database: 4.1.2.10
CAS: 9024-43-5

DBGET integrated database retrieval system