KEGG   ENZYME: 4.1.2.41Help
Entry
EC 4.1.2.41                 Enzyme                                 

Name
vanillin synthase;
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA [RN:R05773]
Reaction(KEGG)
Substrate
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
Product
vanillin [CPD:C00755];
acetyl-CoA [CPD:C00024]
Comment
Involved, together with EC 4.2.1.101 trans-feruloyl-CoA hydratase, in the production of vanillin from trans-ferulic acid. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase.
History
EC 4.1.2.41 created 2000
Pathway
Phenylalanine metabolism
Biosynthesis of secondary metabolites
Orthology
K18383  
trans-feruloyl-CoA hydratase / vanillin synthase
Genes
XCC: 
XCC0810(fadB)
XCB: 
XCA: 
XCP: 
XCV: 
XCV0918(paaF)
XAC: 
XAC0883(fadB)
XCI: 
XCT: 
XCU: 
XCN: 
XCW: 
XCR: 
XCM: 
XCF: 
XCJ: 
XFU: 
XAX: 
XACM_0864(paaF)
XAO: 
XOO: 
XOO3728(fadB)
XOM: 
XOO3520(XOO3520)
XOP: 
XOY: 
XOR: 
XOZ: 
XAL: 
XSA: 
PPU: 
PP_3358(ech)
PPF: 
PPW: 
PPUT: 
PFV: 
POR: 
PST: 
PSB: 
PSYR: 
PSP: 
PPRC: 
PPRO: 
PPC_3628(paaG)
PFS: 
PFE: 
PPZ: 
PTV: 
PBA: 
PBC: 
PSK: 
PCH: 
PCZ: 
PCP: 
PFZ: 
PSES: 
PSCI_1563(paaG)
PSEM: 
PSOS: 
AVN: 
AVL: 
AVD: 
ACX: 
ACB: 
ABY: 
ABAYE2628(hcaA)
ABN: 
ABB: 
ABAB: 
ABAZ: 
ABAU: 
ABAA: 
ABAL: 
ACC: 
ANO: 
ACD: 
ACI: 
ACIAD1726(hcaA)
AEI: 
CSA: 
HAM: 
GSN: 
RSO: 
RSp0225(fca)
RSL: 
RSN: 
RSM: 
RSE: 
REU: 
BMA: 
BML: 
BMN: 
BMAL: 
BMAE: 
BMAQ: 
BMAI: 
BMAF: 
BMAZ: 
BMAB: 
BPS: 
BPM: 
BPL: 
BPSE: 
BPSM: 
BPSU: 
BPSD: 
BPZ: 
BPQ: 
BPSH: 
BPSA: 
BVI: 
BVE: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BCEN: 
BCEW: 
BCEO: 
BAM: 
BAC: 
BMU: 
BMK: 
BMUL: 
BCT: 
BCED: 
BDL: 
BPYR: 
BCON: 
BGL: 
BGP: 
BGU: 
BUG: 
BGE: 
BGF: 
BGD: 
BGO: 
BUK: 
BUL: 
BUB: 
BUQ: 
BPLA: 
BUD: 
BPX: 
BPY: 
PPK: 
PPNO: 
PPNM: 
PRB: 
PPUL: 
PSPU: 
PAPI: 
PVE: 
POX: 
PFG: 
PNR: 
CDN: 
DAC: 
DEL: 
MASW: 
MLO: 
AVI: 
Avi_1705(fadB)
REC: 
REI: 
REP: 
RLE: 
RLT: 
RLG: 
RLB: 
RLU: 
RHL: 
NGL: 
NGG: 
MET: 
META: 
RHZ: 
CCR: 
CCS: 
CAK: 
CSE: 
BSB: 
NAR: 
NPP: 
NPN: 
SPHI: 
SSAN: 
SJP: 
SCH: 
SSY: 
SLG_07870(ferB2) SLG_25030(ferB)
ERY: 
AAY: 
RPM: 
AZL: 
REB: 
SEN: 
SVI: 
AMQ: 
PSEE: 
PSEQ: 
PECQ: 
AMI: 
KAL: 
SUS: 
 » show all
Taxonomy
Reference
1  [PMID:9611814]
  Authors
Narbad A, Gasson MJ.
  Title
Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens.
  Journal
Microbiology. 144 ( Pt 5) (1998) 1397-405.
Reference
2  [PMID:6870241]
  Authors
Pometto AL 3rd, Crawford DL.
  Title
Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus.
  Journal
Appl. Environ. Microbiol. 45 (1983) 1582-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
449168-60-9

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