KEGG   ENZYME: 4.1.2.54Help
Entry
EC 4.1.2.54                 Enzyme                                 

Name
L-threo-3-deoxy-hexylosonate aldolase;
GAAC;
LGA1
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde [RN:R10550]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-L-galactonate [CPD:C20680]
Product
pyruvate [CPD:C00022];
L-glyceraldehyde [CPD:C02426]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
History
EC 4.1.2.54 created 2013
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K18103  L-threo-3-deoxy-hexylosonate aldolase
Genes
SLB: AWJ20_3293
NCR: NCU09532
NTE: NEUTE1DRAFT115768(NEUTE1DRAFT_115768)
SMP: SMAC_06596
PAN: PODANSg8696
TTT: THITE_2107318
MTM: MYCTH_87557
CTHR: CTHT_0029160
MGR: MGG_07462
TMN: UCRPA7_6928
MAW: MAC_02116
MAJ: MAA_01503
CMT: CCM_03105
MBE: MBM_04252
ANI: AN2859.2
ANG: ANI_1_1080024(An02g07720)
ABE: ARB_05689
TVE: TRV_03692
PTE: PTT_12089
 » show all
Taxonomy
Reference
1  [PMID:17609199]
  Authors
Hilditch S, Berghall S, Kalkkinen N, Penttila M, Richard P
  Title
The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase.
  Journal
J. Biol. Chem. 282 (2007) 26195-201.
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal. Genet. Biol. 45 (2008) 1449-57.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.54
IUBMB Enzyme Nomenclature: 4.1.2.54
ExPASy - ENZYME nomenclature database: 4.1.2.54
BRENDA, the Enzyme Database: 4.1.2.54

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