KEGG   ENZYME: 4.1.2.54Help
Entry
EC 4.1.2.54                 Enzyme                                 

Name
L-threo-3-deoxy-hexylosonate aldolase;
GAAC;
LGA1
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde [RN:R10550]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-L-galactonate [CPD:C20680]
Product
pyruvate [CPD:C00022];
L-glyceraldehyde [CPD:C02426]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
History
EC 4.1.2.54 created 2013
Pathway
Pentose and glucuronate interconversions
Metabolic pathways
Orthology
K18103  
L-threo-3-deoxy-hexylosonate aldolase
Genes
NCR: 
NTE: 
NEUTE1DRAFT115768(NEUTE1DRAFT_115768)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1330154(AO090003000752)
ANG: 
ANI_1_1080024(An02g07720)
AFV: 
ACT: 
NFI: 
PCS: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
BCOM: 
NPA: 
HIR: 
FME: 
GTR: 
SLA: 
 » show all
Taxonomy
Reference
1  [PMID:17609199]
  Authors
Hilditch S, Berghall S, Kalkkinen N, Penttila M, Richard P
  Title
The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase.
  Journal
J. Biol. Chem. 282 (2007) 26195-201.
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal. Genet. Biol. 45 (2008) 1449-57.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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