Entry |
|
Name |
indole-3-glycerol-phosphate lyase;
tryptophan synthase alpha;
TSA;
indoleglycerolphosphate aldolase;
indole glycerol phosphate hydrolase;
indole synthase;
indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase;
indole-3-glycerol phosphate lyase;
IGL;
BX1;
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase
|
Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
 |
Sysname |
(1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)
|
Reaction(IUBMB) |
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate [RN: R02340]
|
Reaction(KEGG) |
|
Substrate |
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate [CPD: C03506]
|
Product |
indole [CPD: C00463];
D-glyceraldehyde 3-phosphate [CPD: C00118]
|
Comment |
Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses the first committed step in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) [1]. This enzyme resembles the alpha-subunit of EC 4.2.1.20, tryptophan synthase [3], for which, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate is also a substrate, but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released [2].
|
History |
EC 4.1.2.8 created 1961, deleted 1972, reinstated 2006
|
Pathway |
| Benzoxazinoid biosynthesis |
|
Orthology |
| indole-3-glycerol-phosphate lyase |
|
Genes |
OSA: | | DOSA: | | OBR: | | BDI: | | SBI: | | ZMA: | | SITA: | |
 |
Reference |
|
Authors |
YANOFSKY C. |
Title |
The enzymatic conversion of anthranilic acid to indole. |
Journal |
J. Biol. Chem. 223 (1956) 171-84. |
Reference |
|
Authors |
Frey M, Chomet P, Glawischnig E, Stettner C, Grun S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A. |
Title |
Analysis of a chemical plant defense mechanism in grasses. |
Journal |
Science. 277 (1997) 696-9. |
Sequence |
|
Reference |
|
Authors |
Frey M, Stettner C, Pare PW, Schmelz EA, Tumlinson JH, Gierl A. |
Title |
An herbivore elicitor activates the gene for indole emission in maize. |
Journal |
Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 14801-6. |
Reference |
|
Authors |
Melanson D, Chilton MD, Masters-Moore D, Chilton WS. |
Title |
A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize. |
Journal |
Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13345-50. |
Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9014-52-2 |