KEGG   ENZYME: 4.1.3.22Help
Entry
EC 4.1.3.22                 Enzyme                                 

Name
citramalate lyase;
citramalate pyruvate-lyase;
citramalate synthase;
citramalic-condensing enzyme;
citramalate synthetase;
citramalic synthase;
(S)-citramalate lyase;
(+)-citramalate pyruvate-lyase;
citramalate pyruvate lyase;
(3S)-citramalate pyruvate-lyase;
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming)
Reaction(IUBMB)
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate [RN:R00325]
Reaction(KEGG)
Substrate
(2S)-2-hydroxy-2-methylbutanedioate [CPD:C02614]
Product
acetate [CPD:C00033];
pyruvate [CPD:C00022]
Comment
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.11 (citramalate CoA-transferase) and EC 4.1.3.25 (citramalyl-CoA lyase).
History
EC 4.1.3.22 created 1972
Pathway
C5-Branched dibasic acid metabolism
Reference
1  [PMID:4301387]
  Authors
Barker HA.
  Title
Citramalate lyase of Clostridium tetanomorphum.
  Journal
Arch. Mikrobiol. 59 (1967) 4-12.
  Organism
Clostridium tetanomorphum
Reference
2  [PMID:923590]
  Authors
Dimroth P, Buckel W, Loyal R, Eggerer H.
  Title
Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase.
  Journal
Eur. J. Biochem. 80 (1977) 469-77.
  Organism
Clostridium tetanomorphum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-93-4

DBGET integrated database retrieval system