KEGG   ENZYME: 4.1.3.25Help
Entry
EC 4.1.3.25                 Enzyme                                 

Name
(S)-citramalyl-CoA lyase;
citramalyl coenzyme A lyase (ambiguous);
(+)-CMA-CoA lyase;
(3S)-citramalyl-CoA pyruvate-lyase;
Mcl (ambiguous);
citramalyl-CoA lyase (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
(3S)-citramalyl-CoA = acetyl-CoA + pyruvate [RN:R00237]
Reaction(KEGG)
Substrate
(3S)-citramalyl-CoA [CPD:C01011]
Product
acetyl-CoA [CPD:C00024];
pyruvate [CPD:C00022]
Comment
Requires Mg2+ ions for activity [3]. The enzyme from the bacterium Clostridium tetanomorphum is a component of EC 4.1.3.22, citramalate lyase [2]. It also acts on (3S)-citramalyl thioacyl-carrier protein [2]. The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC 4.1.3.24, malyl-CoA lyase [3]. It has no activity with (3R)-citramalyl-CoA (cf. EC 4.1.3.46, (R)-citramalyl-CoA lyase) [3].
History
EC 4.1.3.25 created 1972, modified 2014
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase
K18292  (S)-citramalyl-CoA lyase
Genes
STM: STM3120
SEO: STM14_3769
SEV: STMMW_30801
SEY: SL1344_3094
SEM: STMDT12_C31730
SEJ: STMUK_3108
SEB: STM474_3269(cilB)
SEF: UMN798_3390(citE)
SETU: STU288_15790
SETC: CFSAN001921_01425
SENR: STMDT2_30141(citE)
SEI: SPC_3187
SEC: SCH_3060(cilB)
SHB: SU5_03618
SED: SeD_A3464
SEG: SG3014
SEL: SPUL_3123
SET: SEN2963
SENA: AU38_15060
SENO: AU37_15070
SENV: AU39_15065
SENQ: AU40_16980
SENL: IY59_15670
SEEP: I137_14925
SENE: IA1_15060
YPE: YPO1928
YPK: y2383
YPA: YPA_1306
YPM: YP_1670(citE2)
YPD: YPD4_1695
YPX: YPD8_1853
YPW: CH59_3724
YPV: BZ15_1614
YPL: CH46_3187
YPS: YPTB1926
YPO: BZ17_545
YPY: YPK_2266
YPB: YPTS_1975
YPQ: DJ40_389
YPU: BZ21_1197
YPR: BZ20_192
YPC: BZ23_1480
YPF: BZ19_1272
SOD: Sant_0823
PAE: PA0883
PAEV: N297_911
PAEI: N296_911
PAEP: PA1S_22025
PAEM: U769_21395
PAEL: T223_22660
PAEG: AI22_11915
PAEC: M802_907
PAEO: M801_911
PMK: MDS_3403
PPSE: BN5_1317(citE)
PCQ: PcP3B5_31100(citE)
PPI: YSA_10989
PPUN: PP4_26630
PSB: Psyr_2171
PFL: PFL_2651
PPRC: PFLCHA0_c27180(citE)
PPRO: PPC_2700
PFS: PFLU_3472
PFB: VO64_0585
PSA: PST_1698
PSTT: CH92_08230
PKC: PKB_4384
PSES: PSCI_4465
PSEM: TO66_12960
PSIL: PMA3_18315
PALI: A3K91_1706
PSYA: AOT82_731
MCS: DR90_1496
MCAT: MC25239_00424(mcl2)
MICC: AUP74_02899(mcl2)
LLO: LLO_3025
TMC: LMI_0901(citE)
MCA: MCA1739
FPZ: LA55_827
FNA: OOM_1389
ADI: B5T_02014(citE)
APAC: S7S_06580
AXE: P40_09630
OCE: GU3_13905
CNC: CNE_BB1p10140(mcl)
BMA: BMAA1653
BMAL: DM55_3233
BMAE: DM78_4163
BMAQ: DM76_3931
BMAI: DM57_07710
BMAF: DM51_3351
BMAZ: BM44_3169
BMAB: BM45_4008
BPS: BPSS1639
BPD: BURPS668_A2305(cilB)
BPSE: BDL_4992
BPSM: BBQ_4502
BPSU: BBN_5092
BPSD: BBX_4158
BPK: BBK_4298
BPSH: DR55_3631
BPSA: BBU_4388
BPSO: X996_5997
BUT: X994_5469
BOK: DM82_5767
BOC: BG90_4866(cilB)
BPH: Bphy_5924
PPUL: RO07_22660
BPA: BPP3643
BPAR: BN117_1034
BBR: BB4078
BPT: Bpet0820
BAV: BAV0715(citE)
BHO: D560_1018
BHM: D558_1004
BTRM: SAMEA390648700434(citE)
TEA: KUI_1572
TEG: KUK_0903
TAS: TASI_1543
TAT: KUM_1148
PUT: PT7_0057
AMIM: MIM_c40120
BPSI: IX83_01500
CBAB: SMCB_1586
MPT: Mpe_A3254
METR: BSY238_253
CCQ: N149_0442
CCY: YSS_02015
CCOF: VC76_02330(citE)
CCOO: ATE51_03324(citE)
PLA: Plav_3098
BRAD: BF49_2901
XAU: Xaut_3870
AZC: AZC_1227
MDI: METDI2485(mcl) METDI4906
MAQU: Maq22A_c18385(citE) Maq22A_c19250(mcl)
BID: Bind_2534
MSL: Msil_1719
HDN: Hden_1659
RVA: Rvan_1682
BVR: BVIR_1803
MCG: GL4_3371
HDI: HDIA_2467(mcl1_2)
RBM: TEF_05695
CCR: CC_2999
CAK: Caul_0731
CSE: Cseg_3490
SIL: SPO1565 SPO3608(mclA)
RSP: RSP_1771
RCP: RCAP_rcc03164(citE2)
JAN: Jann_0471
RDE: RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI: RLO149_c002070(mcl1) RLO149_c036850(mcl2)
PDE: Pden_0799
DSH: Dshi_3050(citE2)
PSF: PSE_3167(clybl) PSE_3192
PGD: Gal_00369
OTM: OSB_28710(mcl1)
PTP: RCA23_c05980(mclA)
CID: P73_4243
MALG: MALG_03008
RSU: NHU_02809
RHC: RGUI_3145
SPSE: SULPSESMR1_03496(mcl1)
RMM: ROSMUCSMR3_02149(mcl1)
LVS: LOKVESSMR4R_02838(mcl1)
AHT: ANTHELSMS3_00280(mcl1)
HNE: HNE_0078(mclA)
HBA: Hbal_0778
SPHM: G432_00485
SPHI: TS85_14850
SPHD: HY78_18245
SFLA: SPHFLASMR4Y_02129(mcl1)
BLAS: BSY18_3094
ANH: A6F65_00045(mcl2_1)
ADO: A6F68_02607(mcl2)
RRU: Rru_A0217
RRF: F11_01090
MAG: amb3977
MAGX: XM1_1373
MAGN: WV31_14965
TMO: TMO_0350(citE) TMO_b0387
TXI: TH3_02680
MAGQ: MGMAQ_0659
MSY: MS53_0535
MUL: MUL_4021(citE_1)
MMI: MMAR_4158(citE_1)
MMAE: MMARE11_39680(citE_1)
MLI: MULP_04326(citE_1)
CPSE: CPTA_01732
CPSU: CPTB_02031
CPSF: CPTC_01723
SCT: SCAT_4364
SBH: SBI_09084
SALU: DC74_4078
SALL: SAZ_21750
STRE: GZL_04819
SLD: T261_4311
STRM: M444_14915
KSK: KSE_23700
NCA: Noca_4393
NDK: I601_0974(mcl1)
PSIM: KR76_23920
AMD: AMED_0079(citE)
AMN: RAM_00395
AMM: AMES_0076(citE)
AMZ: B737_0077(citE)
AOI: AORI_0068(mcl)
AMQ: AMETH_0090(citE)
PSEE: FRP1_04910
KAL: KALB_2473
ALL: CRK61727
CWO: Cwoe_4213
RCA: Rcas_0912
CAU: Caur_0174
CAG: Cagg_1328
 » show all
Taxonomy
Reference
1  [PMID:4284209]
  Authors
Cooper RA, Kornberg HL.
  Title
The utilization of itaconate by Pseudomonas sp.
  Journal
Biochem. J. 91 (1964) 82-91.
Reference
2  [PMID:923590]
  Authors
Dimroth P, Buckel W, Loyal R, Eggerer H.
  Title
Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase.
  Journal
Eur. J. Biochem. 80 (1977) 469-77.
Reference
3  [PMID:17259315]
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J. Bacteriol. 189 (2007) 2906-14.
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.25
IUBMB Enzyme Nomenclature: 4.1.3.25
ExPASy - ENZYME nomenclature database: 4.1.3.25
BRENDA, the Enzyme Database: 4.1.3.25
CAS: 37290-68-9

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