KEGG   ENZYME: 4.1.3.26Help
Entry
EC 4.1.3.26                 Enzyme                                 

Name
3-hydroxy-3-isohexenylglutaryl-CoA lyase;
beta-hydroxy-beta-isohexenylglutaryl CoA-lyase;
hydroxyisohexenylglutaryl-CoA:acetatelyase;
3-hydroxy-3-isohexenylglutaryl coenzyme A lyase;
3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
Reaction(IUBMB)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate [RN:R08090]
Reaction(KEGG)
Substrate
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]
Product
7-methyl-3-oxooct-6-enoyl-CoA;
acetate [CPD:C00033]
Comment
Also acts on the hydroxy derivative of farnesoyl-CoA.
History
EC 4.1.3.26 created 1972
Pathway
Geraniol degradation
Biosynthesis of secondary metabolites
Reference
1  [PMID:14339651]
  Authors
SEUBERT W, FASS E.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]
  Journal
Biochem. Z. 341 (1964) 23-34.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37290-69-0

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