| Entry |
|
|---|
| Name |
1,4-dihydroxy-2-naphthoyl-CoA synthase;
naphthoate synthase;
1,4-dihydroxy-2-naphthoate synthase;
dihydroxynaphthoate synthase;
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing),
MenB |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
|---|
| Sysname |
o-succinylbenzoyl-CoA dehydratase (cyclizing) |
|---|
| Reaction(IUBMB) |
o-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
[RN:R04150] |
|---|
| Reaction(KEGG) |
R04150;
(other) R07263
 |
|---|
| Substrate |
o-succinylbenzoyl-CoA [CPD:C03160] |
|---|
| Product |
1,4-dihydroxy-2-naphthoyl-CoA [CPD:C15547];
H2O [CPD:C00001] |
|---|
| Comment |
This enzyme is involved in the synthesis of
1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the
biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone
(vitamin K1 in plants), and many plant pigments.
The coenzyme A group is subsequently removed from the product by an
as-yet uncharacterized thioesterase [3]. |
|---|
| Pathway |
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01100 Metabolic pathways
ec01110 Biosynthesis of secondary metabolites |
|---|
| Orthology |
K01661 naphthoate synthase |
|---|
| Genes |
ATH: AT1G60550(ECHID)
POP: POPTR_829783
RCU: RCOM_0527990
VVI: 100246470
OSA: 4327859(Os01g0662700)
SBI: SORBI_04g003790
ZMA: 100304279
PPP: PHYPADRAFT_141103
CRE: CHLREDRAFT_112040(MEN2)
OLU: OSTLU_40076
PTI: PHATRDRAFT_bd371
ECO: b2262(menB)
ECJ: JW2257(menB)
ECD: ECDH10B_2423(menB)
EBW: BWG_2036(menB)
ECE: Z3522(menB)
ECS: ECs3150
ECF: ECH74115_3404(menB)
ETW: ECSP_3140(menB)
EOJ: ECO26_3253(menB)
EOI: ECO111_3013(menB)
EOH: ECO103_2729(menB)
ECG: E2348C_2407(menB)
EOK: G2583_2803(menB)
ECC: c2805(menB)
ECP: ECP_2306
ECI: UTI89_C2545(menB)
ECV: APECO1_4299(menB)
ECX: EcHS_A2408(menB)
ECW: EcE24377A_2558(menB)
ECM: EcSMS35_2417(menB)
ECY: ECSE_2522
ECR: ECIAI1_2340(menB)
ECQ: ECED1_2730(menB)
ECK: EC55989_2510(menB)
ECT: ECIAI39_2410(menB)
EUM: ECUMN_2605(menB)
ECZ: ECS88_2413(menB)
ECL: EcolC_1386
EBR: ECB_02189(menB)
EBD: ECBD_1396
EFE: EFER_0906(menB)
STY: STY2537(menB)
STT: t0556(menB)
STM: STM2307(menB)
SPT: SPA0556(menB)
SEK: SSPA0520
SPQ: SPAB_00674
SEI: SPC_1404(menB)
SEC: SC2307(menB)
SEH: SeHA_C2547(menB)
SEE: SNSL254_A2492(menB)
SEW: SeSA_A2535(menB)
SEA: SeAg_B2443(menB)
SED: SeD_A2651(menB)
SEG: SG2336(menB)
SET: SEN2289(menB)
SES: SARI_00592
YPE: YPO2525(menB)
YPK: y1662(menB)
YPA: YPA_2017
YPN: YPN_2120
YPM: YP_2336(menB)
YPP: YPDSF_1935
YPG: YpAngola_A1783(menB)
YPZ: YPZ3_2231(menB)
YPS: YPTB2558(menB)
YPI: YpsIP31758_1484(menB)
YPY: YPK_1591
YPB: YPTS_2652
YEN: YE1377(menB)
SFL: SF2341(menB)
SFX: S2475(menB)
SFV: SFV_2333(menB)
SSN: SSON_2323(menB)
SBO: SBO_2299(menB)
SBC: SbBS512_E2641(menB)
SDY: SDY_2458(menB)
ECA: ECA1213(menB)
PCT: PC1_1113
PWA: Pecwa_3201
EBI: EbC_30500(menB)
PLU: plu3071(menB)
PAY: PAU_01540(menB)
ENT: Ent638_2812
ENC: ECL_03612(menB)
ESA: ESA_00951
CTU: Ctu_28940(menB)
KPN: KPN_02660(menB)
KPE: KPK_1489(menB)
KPU: KP1_3901(menB)
KVA: Kvar_1393
CKO: CKO_00528
CRO: ROD_26691(menB)
SPE: Spro_3281
PMR: PMI1743(menB)
EIC: NT01EI_2648
ETR: ETAE_2356(menB)
DDA: Dd703_1047
DDC: Dd586_1088
DZE: Dd1591_3012
XBO: XBJ1_0738(menB)
XNE: XNC1_2847(menB)
HIN: HI0968(menB)
HIT: NTHI1141(menB)
HIP: CGSHiEE_07120
HIQ: CGSHiGG_08420
HDU: HD1925(menB)
HAP: HAPS_1422(menB)
HSO: HS_0562(menB)
HSM: HSM_1612
PMU: PM1096(menB)
MSU: MS1792(menB)
APL: APL_1824(menB)
APJ: APJL_1860(menB)
APA: APP7_1910
ASU: Asuc_0650
AAP: NT05HA_0091
AAT: D11S_2096
VCH: VC1973
VCO: VC0395_A1559(menB)
VCM: VCM66_1897(menB)
VCJ: VCD_002394
VVU: VV1_3170
VVY: VV1118
VPA: VP0931
VHA: VIBHAR_01431
VSP: VS_2189
VEX: VEA_004030
VFI: VF_1669(menB)
VFM: VFMJ11_1794(menB)
VSA: VSAL_I1101(menB)
PPR: PBPRB1048 PBPRB1049
SON: SO_4739(menB)
SFR: Sfri_4030
SAZ: Sama_3635
SBL: Sbal_4340
SBM: Shew185_4358
SBN: Sbal195_4500
SBP: Sbal223_4303
SLO: Shew_3814
SPC: Sputcn32_3920
SSE: Ssed_4478
SPL: Spea_4225
SHE: Shewmr4_3918
SHM: Shewmr7_4010
SHN: Shewana3_4123
SHW: Sputw3181_4046
SHL: Shal_4273
SWD: Swoo_4886
SWP: swp_5136
SVO: SVI_4314(menB)
PIN: Ping_0350
TTU: TERTU_2726(menB)
ALV: Alvin_0624
HHA: Hhal_1129
AHA: AHA_0529(menB)
ASA: ASA_3735(menB)
TAU: Tola_0431
CVI: CV_1330
REU: Reut_B3916 Reut_C6107
REH: H16_B1695(menB)
CTI: RALTA_B1488(badI)
BCM: Bcenmc03_6839
BXE: Bxe_C1035
PNA: Pnap_2124
VEI: Veis_0222 Veis_4105
LCH: Lcho_1186
DAR: Daro_1616
APP: CAP2UW1_3140
LIP: LI0807(menB)
BBA: Bd3492(menB)
DPS: DP0252
DAL: Dalk_1406
MXA: MXAN_3154(menB)
SCL: sce5310(menB)
HOH: Hoch_6464
SAT: SYN_02400
MES: Meso_2953
PLA: Plav_1770
RPC: RPC_1033
RPE: RPE_0612
RPT: Rpal_0720
XAU: Xaut_0912
BSU: BSU30800(menB)
BAN: BA_5109(menB)
BAR: GBAA_5109(menB)
BAT: BAS4748
BAH: BAMEG_5143(menB)
BAI: BAA_5121(menB)
BAL: BACI_c48590(menB)
BCE: BC4853
BCA: BCE_5013(menB)
BCZ: BCZK4608(menB)
BCR: BCAH187_A4995(menB)
BCB: BCB4264_A4984(menB)
BCU: BCAH820_4966(menB)
BCG: BCG9842_B0254(menB)
BCQ: BCQ_4671(menB)
BCX: BCA_4989(menB)
BCY: Bcer98_3491
BTK: BT9727_4586(menB)
BTL: BALH_4419(menB)
BTB: BMB171_C4492(menB)
BWE: BcerKBAB4_4695
BLI: BL02406(menB)
BLD: BLi03220(menB)
BAY: RBAM_027780(menB)
BPU: BPUM_2716(menB)
BMQ: BMQ_4889(menB)
BMD: BMD_4875(menB)
OIH: OB2323
GKA: GK2873
GTN: GTNG_2771
GWC: GWCH70_2797
GYC: GYMC61_0570
GCT: GC56T3_0614
AFL: Aflv_0383(menB)
SAU: SA0898(menB)
SAV: SAV1045(menB)
SAW: SAHV_1038(menB)
SAH: SaurJH1_1127
SAJ: SaurJH9_1104
SAM: MW0929(menB)
SAS: SAS0981
SAR: SAR1019(menB)
SAC: SACOL1054(menB)
SAX: USA300HOU_0993(menB)
SAA: SAUSA300_0948(menB)
SAO: SAOUHSC_00985
SAE: NWMN_0915(memB)
SAD: SAAV_1009(menB)
SAB: SAB0912(menB)
SEP: SE0746
SER: SERP0632(menB)
SHA: SH1917(menB)
SSP: SSP1746
SCA: Sca_0654(menB)
SLG: SLGD_01827
LMO: lmo1673(menB)
LMF: LMOf2365_1697(menB)
LMH: LMHCC_0893(menB)
LMC: Lm4b_01686(menB)
LMN: LM5578_1820(menB)
LMY: LM5923_1772(menB)
LIN: lin1781
LWE: lwe1691(menB)
LSG: lse_1641(menB)
LSP: Bsph_4275
ESI: Exig_0625
EAT: EAT1b_2372
MCL: MCCL_1505(menB)
AAC: Aaci_1210 Aaci_1921
BTS: Btus_1276
LLA: L0171(menB)
LLK: LLKF_0749(menB)
LLC: LACR_0771
LLM: llmg_1831(menB)
LSL: LSL_0174(menB)
LBR: LVIS_0066
LRE: Lreu_0887
LRF: LAR_0833
LFE: LAF_0969
EFA: EF0445(menB)
OOE: OEOE_0279
LME: LEUM_0016
LCI: LCK_01696(menB)
LKI: LKI_02990
LGS: LEGAS_1895(menB)
VPR: Vpar_0376
DSY: DSY0520(menB)
DHD: Dhaf_0472
MTU: Rv0548c(menB)
MTC: MT0573(menB)
MRA: MRA_0555(menB)
MTF: TBFG_10559
MTB: TBMG_00554(TBMG_00554.1)
MBO: Mb0562c(menB)
MBB: BCG_0592c(menB)
MBT: JTY_0562(menB)
MLE: ML2263(menB)
MLB: MLBr_02263(menB)
MPA: MAP4044c(menB)
MAV: MAV_4596(menB)
MSM: MSMEG_1075(menB) MSMEG_4114(menB)
MUL: MUL_0648(menB)
MVA: Mvan_0947
MGI: Mflv_0025
MAB: MAB_3945
MMC: Mmcs_0735
MKM: Mkms_0749
MJL: Mjls_0729
MMI: MMAR_0895(menB)
CGL: NCgl0446(cgl0463)
CGB: cg0548(menB)
CGT: cgR_0566
CEF: CE0475 CE2780
CDI: DIP0421(menB)
CJK: jk1870(menB)
CAR: cauri_0338(menB)
CKP: ckrop_1888
CPU: cpfrc_00293(menB)
NFA: nfa51380(menB)
RHA: RHA1_ro02003 RHA1_ro02630 RHA1_ro11181(menB)
RER: RER_16980(menB)
ROP: ROP_16770(menB) ROP_23830(menB) ROP_45870(menB) ROP_46000(menB)
ROP_pROB02-01530
GBR: Gbro_1084 Gbro_2930
TPR: Tpau_0717
SRT: Srot_2754
TWH: TWT110(menB)
TWS: TW120(menB)
LXX: Lxx01440(menB)
CMI: CMM_0576(menB)
CMS: CMS_2584(menB)
ART: Arth_3283
AAU: AAur_3275(menB)
ACH: Achl_3077
RSA: RSal33209_2700
KRH: KRH_04970(menB)
MLU: Mlut_17880
RMU: RMDY18_03640
BCV: Bcav_3243
BFA: Bfae_24180
JDE: Jden_0531
KSE: Ksed_24150
XCE: Xcel_0455
SKE: Sked_07300
CFL: Cfla_2724
PAC: PPA0907
PAK: HMPREF0675_3964(menB)
PFR: PFREUD_07540(menB)
NCA: Noca_0258 Noca_4299
KFL: Kfla_0324
TFU: Tfu_1409
NDA: Ndas_2567
TCU: Tcur_2404
SRO: Sros_0516
NML: Namu_0879 Namu_0941
GOB: Gobs_0331
KRA: Krad_0641
SEN: SACE_6914(menB)
SVI: Svir_03100
TBI: Tbis_1707
AMD: AMED_0509(menB)
AMI: Amir_6701
SNA: Snas_0110
AHE: Arch_0285
MCU: HMPREF0573_10976(menB)
RXY: Rxyl_2893
CWO: Cwoe_2333 Cwoe_3569
AFO: Afer_0255
CCU: Ccur_14020
SHI: Shel_04140
ELE: Elen_2972
PCU: pc1064(menB)
WCH: wcw_1027(menB)
BTH: BT_4702
BFR: BF1318
BFS: BF1303(menB)
BVU: BVU_2417
PGI: PG1523(menB)
PDI: BDI_1137
PRU: PRU_1684(menB)
PMZ: HMPREF0659_A6050(menB)
SRU: SRU_2766(menB)
SRM: SRM_02979(menB)
RMR: Rmar_0922
CHU: CHU_1897(menB)
DFE: Dfer_1216
SLI: Slin_1753
GFO: GFO_2070(menB)
FJO: Fjoh_2784
FPS: FP0478(menB)
FBA: FIC_01440
COC: Coch_0505
RBI: RB2501_14984
ZPR: ZPR_1722
CAT: CA2559_10533
BBL: BLBBGE_267(menB)
BPI: BPLAN_369(menB)
OTE: Oter_3116
CAA: Caka_0851
AMU: Amuc_0351
SYN: sll1127(menB)
SYW: SYNW0998(menB)
SYC: syc0926_d(menB)
SYF: Synpcc7942_0597
SYD: Syncc9605_1123
SYE: Syncc9902_1333
SYG: sync_1527(menB)
SYR: SynRCC307_1141(menB)
SYX: SynWH7803_1022(menB)
SYP: SYNPCC7002_A0268(menB)
CYA: CYA_0530(menB)
CYB: CYB_0565(menB)
TEL: tll2458(menB)
MAR: MAE_45860(menB)
CYT: cce_0831(menB)
CYP: PCC8801_0257
CYC: PCC7424_1611
CYN: Cyan7425_4674
CYH: Cyan8802_0255
CYU: UCYN_05740
ANA: all2347
NPU: Npun_R3968
AVA: Ava_0166
NAZ: Aazo_0919
PMA: Pro1053(menB)
PMM: PMM0608(menB)
PMT: PMT0405(menB)
PMN: PMN2A_0044
PMI: PMT9312_0608
PMB: A9601_06641(menB)
PMC: P9515_06731(menB)
PMF: P9303_18811(menB)
PMG: P9301_06341(menB)
PMH: P9215_06901(menB)
PMJ: P9211_10421
PME: NATL1_06641(menB)
TER: Tery_4088
AMR: AM1_5258(menB)
CTE: CT1846(menB)
CPC: Cpar_0357
CCH: Cag_1719
CPH: Cpha266_2091
CPB: Cphamn1_2077
CLI: Clim_2050
PVI: Cvib_0394
PLT: Plut_0328
PPH: Ppha_2433
PAA: Paes_1880
CTS: Ctha_1987
RRS: RoseRS_0024
RCA: Rcas_4218
CAU: Caur_0094
CAG: Cagg_1162
CHL: Chy400_0100
TRO: trd_A0304(menB)
STI: Sthe_3019
TTR: Tter_1231
FPL: Ferp_1040
HAL: VNG1079G(menB)
HSL: OE2561R(menB)
HMA: rrnAC0841(ech1)
HWA: HQ1874A(menB)
NPH: NP2730A(menB)
HLA: Hlac_2150
HUT: Huta_0395
HMU: Hmuk_2252
HTU: Htur_1780
NMG: Nmag_3561
HVO: HVO_1465(menB)
HJE: HacjB3_08350
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:500558]
Meganathan R, Bentley R.
Menaquinone (vitamin K2) biosynthesis: conversion of
o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by
Mycobacterium phlei enzymes.
J. Bacteriol. 140 (1979) 92-8.
Mycobacterium phlei |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2966501]
Kolkmann R, Leistner E.
4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate
in vitamin K2 (menaquinone) biosynthesis.
Z. Naturforsch. [C]. 42 (1987) 1207-14.
Mycobacterium phlei, Escherichia coli [GN:eco], Galium mollugo |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:10722690]
Johnson TW, Shen G, Zybailov B, Kolling D, Reategui R, Beauparlant
S, Vassiliev IR, Bryant DA, Jones AD, Golbeck JH, Chitnis PR
Recruitment of a foreign quinone into the A(1) site of photosystem
I. I. Genetic and physiological characterization of phylloquinone
biosynthetic pathway mutants in Synechocystis sp. pcc 6803.
J. Biol. Chem. 275 (2000) 8523-30. |
|---|
Reference
Authors
Title
Journal
|
4 [PMID:12909628]
Truglio JJ, Theis K, Feng Y, Gajda R, Machutta C, Tonge PJ, Kisker
C.
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme
in vitamin K2 biosynthesis.
J. Biol. Chem. 278 (2003) 42352-60. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.3.36
IUBMB Enzyme Nomenclature: 4.1.3.36
ExPASy - ENZYME nomenclature database: 4.1.3.36
BRENDA, the Enzyme Database: 4.1.3.36
CAS: 61328-42-5 |
|---|
