KEGG   ENZYME: 4.1.3.41Help
Entry
EC 4.1.3.41                 Enzyme                                 

Name
3-hydroxy-D-aspartate aldolase;
D-3-hydroxyaspartate aldolase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming)
Reaction(IUBMB)
(1) threo-3-hydroxy-D-aspartate = glycine + glyoxylate [RN:R09717];
(2) D-erythro-3-hydroxyaspartate = glycine + glyoxylate [RN:R09718]
Reaction(KEGG)
Substrate
threo-3-hydroxy-D-aspartate [CPD:C19813];
D-erythro-3-hydroxyaspartate [CPD:C19838]
Product
glycine [CPD:C00037];
glyoxylate [CPD:C00048]
Comment
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the alpha-position of the substrate, but accepts both the threo and erythro forms at the beta-position. The erythro form is a far better substrate (about 100-fold). The enzyme can also accept D-allothreonine, D-threonine, erythro-3-phenyl-D-serine and threo-3-phenyl-D-serine. Different from EC 4.1.3.14, erythro-3-hydroxy-L-aspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.
History
EC 4.1.3.41 created 2011
Orthology
K18425  
3-hydroxy-D-aspartate aldolase
Genes
PAR: 
Psyc_1390(dhaa)
PCR: 
PSO: 
CPS: 
MPQ: 
MES: 
SMI: 
RHI: 
SFD: 
REL: 
REP: 
SNO: 
MRD: 
SIL: 
SIT: 
JAN: 
RDE: 
RLI: 
PDE: 
PAMI: 
DSH: 
OAT: 
OAR: 
OTM: 
OSB_04160(dhaa)
LMD: 
RED: 
MALG: 
 » show all
Taxonomy
Reference
1  [PMID:12835921]
  Authors
Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S
  Title
A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.
  Journal
Appl. Microbiol. Biotechnol. 62 (2003) 53-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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