KEGG   ENZYME: 4.1.3.45Help
Entry
EC 4.1.3.45                 Enzyme                                 

Name
3-hydroxybenzoate synthase;
chorismatase/3-hydroxybenzoate synthase;
hyg5 (gene name);
bra8 (gene name);
XanB2
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Reaction(IUBMB)
chorismate = 3-hydroxybenzoate + pyruvate [RN:R10597]
Reaction(KEGG)
Substrate
chorismate [CPD:C00251]
Product
3-hydroxybenzoate [CPD:C00587];
pyruvate [CPD:C00022]
Comment
The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].
History
EC 4.1.3.45 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase
Genes
XFA: XF_0769
XFT: PD_1889(fkbO)
XFM: Xfasm12_2072
XFN: XfasM23_1994
XFF: XFLM_03915
XFL: P303_00390
XFS: D934_13290
XFH: XFHB_11425
XCC: XCC4014(rapK)
XCB: XC_4103
XCP: XCR_0248
XCV: XCV4191
XAX: XACM_3971
XAC: XAC4103(rapK)
XCI: XCAW_00197(rapK)
XFU: XFF4834R_chr39700(xanB2)
XOO: XOO4322(rapK)
XOM: XOO4072(XOO4072)
XOP: PXO_03739(pigB)
XOR: XOC_0424(pigB)
XAL: XALC_0126
XPH: XppCFBP6546_13945(XppCFBP6546P_13945)
PSUW: WQ53_09330
PSD: DSC_00450
LAQ: GLA29479_4083(xanB2)
LEZ: GLE_4979
LEM: LEN_0460
DKO: I596_56
NOC: Noc_2127
NHL: Nhal_2765
NWA: Nwat_0961
NTT: TAO_1291
TGR: Tgr7_0320
TVR: TVD_06985
 » show all
Taxonomy
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 4776-81.
  Sequence
Reference
2  [PMID:23824670]
  Authors
Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y
  Title
Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.
  Journal
Chembiochem. 14 (2013) 1468-75.
Reference
3  [PMID:23113660]
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol. Microbiol. 87 (2013) 80-93.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.45
IUBMB Enzyme Nomenclature: 4.1.3.45
ExPASy - ENZYME nomenclature database: 4.1.3.45
BRENDA, the Enzyme Database: 4.1.3.45

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