KEGG   ENZYME: 4.1.3.6Help
Entry
EC 4.1.3.6                  Enzyme                                 

Name
citrate (pro-3S)-lyase;
citrase;
citratase;
citritase;
citridesmolase;
citrate aldolase;
citric aldolase;
citrate lyase;
citrate oxaloacetate-lyase;
citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate)
Reaction(IUBMB)
citrate = acetate + oxaloacetate [RN:R00362]
Reaction(KEGG)
Substrate
citrate [CPD:C00158]
Product
acetate [CPD:C00033];
oxaloacetate [CPD:C00036]
Comment
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.
History
EC 4.1.3.6 created 1961
Reference
1  [PMID:13239657]
  Authors
DAGLEY S, DAWES EA.
  Title
Citridesmolase: its properties and mode of action.
  Journal
Biochim. Biophys. Acta. 17 (1955) 177-84.
Reference
2  [PMID:336371]
  Authors
Dimroth P, Loyal R, Eggerer H.
  Title
Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate.
  Journal
Eur. J. Biochem. 80 (1977) 479-88.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-83-3

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