| Entry |
|
|---|
| Name |
benzylsuccinate synthase;
benzylsuccinate fumarate-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
 |
|---|
| Sysname |
benzylsuccinate fumarate-lyase (toluene-forming) |
|---|
| Reaction(IUBMB) |
benzylsuccinate = toluene + fumarate [RN:R05598] |
|---|
| Reaction(KEGG) |
R05598
 |
|---|
| Substrate |
benzylsuccinate [CPD:C09816] |
|---|
| Product |
toluene [CPD:C01455];
fumarate [CPD:C00122] |
|---|
| Comment |
A glycyl radical enzyme that is inhibited by benzyl alcohol,
benzaldehyde, phenylhydrazine and is inactivated by oxygen. |
|---|
| Pathway |
ec00632 Benzoate degradation via CoA ligation
ec01100 Metabolic pathways |
|---|
| Orthology |
K07540 benzylsuccinate synthase |
|---|
| Genes |
EBA: c2A303(bssC) c2A304(bssA) c2A305(bssB)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:9765580]
Beller HR, Spormann AM.
Analysis of the novel benzylsuccinate synthase reaction for
anaerobic toluene activation based on structural studies of the
product.
J. Bacteriol. 180 (1998) 5454-7.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9632263]
Leuthner B, Leutwein C, Schulz H, Horth P, Haehnel W, Schiltz E,
Schagger H, Heider J.
Biochemical and genetic characterization of benzylsuccinate synthase
from Thauera aromatica: a new glycyl radical enzyme catalysing the
first step in anaerobic toluene metabolism.
Mol. Microbiol. 28 (1998) 615-28.
Thauera aromatica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.99.11
IUBMB Enzyme Nomenclature: 4.1.99.11
ExPASy - ENZYME nomenclature database: 4.1.99.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.99.11
BRENDA, the Enzyme Database: 4.1.99.11
CAS: 209264-18-6 |
|---|
