KEGG   ENZYME: 4.2.1.105Help
Entry
EC 4.2.1.105                Enzyme                                 

Name
2-hydroxyisoflavanone dehydratase;
2,7,4'-trihydroxyisoflavanone hydro-lyase;
2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Reaction(IUBMB)
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction(KEGG)
R07317;
(other) R06793 R07723
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Substrate
2,4',7-trihydroxyisoflavanone;
2,4',5,7-tetrahydroxyisoflavanone
Product
daidzein [CPD:C10208];
H2O [CPD:C00001];
genistein [CPD:C06563]
Comment
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
History
EC 4.2.1.105 created 2004, modified 2013
Pathway
Isoflavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13258  
2-hydroxyisoflavanone dehydratase
Genes
GMX: 
547489(HIDH)
PVU: 
VRA: 
MTR: 
CAM: 
Taxonomy
Reference
1
  Authors
Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U.
  Title
Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata.
  Journal
Phytochemistry 49 (1998) 497-505.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
166800-10-8

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