| Entry |
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| Name |
bile-acid 7alpha-dehydratase;
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming)
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| Reaction(IUBMB) |
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate = 12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O [RN: R07318]
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| Reaction(KEGG) |
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| Substrate |
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate [CPD: C15568]
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| Product |
12alpha-hydroxy-3-oxochola-4,6-dienoate [CPD: C15569];
H2O [CPD: C00001]
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| Comment |
The enzyme from Eubacterium sp. strain VPI 12708 can also use 7alpha-hydroxy-3-oxochol-4-enoate as a substrate but not 7alpha,12alpha-dihydroxy-3-oxochol-5beta-anoate, 3alpha,7alpha,12alpha-trihydroxychol-5beta-anoate or 7beta-hydroxy-3-oxochol-4-enoate.
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| Pathway |
| Secondary bile acid biosynthesis |
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| Orthology |
| bile-acid 7alpha-dehydratase |
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| Reference |
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| Authors |
Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB. |
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| Title |
Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. |
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| Journal |
J. Lipid. Res. 37 (1996) 1258-67. |
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| Organism |
Eubacterium sp. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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