| Entry |
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| Name |
methylthioribulose 1-phosphate dehydratase;
1-PMT-ribulose dehydratase;
S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]
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| Reaction(IUBMB) |
S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O [RN: R07392]
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| Reaction(KEGG) |
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| Substrate |
S-methyl-5-thio-D-ribulose 1-phosphate [CPD: C04582]
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| Product |
5-(methylthio)-2,3-dioxopentyl phosphate [CPD: C15650];
H2O [CPD: C00001]
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| Comment |
This enzyme forms part of the methionine-salvage pathway.
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| Pathway |
| Cysteine and methionine metabolism | | Metabolic pathways |
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| Orthology |
| methylthioribulose-1-phosphate dehydratase | | methylthioribulose 1-phosphate dehydratase / enolase-phosphatase E1 |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | CEL: | | CBR: | | NVE: | | HMG: | | TAD: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | VCN: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | LBC: | | CCI: | | MBR: | | NGR: | | DDI: | | DPP: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | PIF: | | YPP: | | YPG: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | DDA: | | DDC: | | DDD: | | DZE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | ROR: | | XFA: | | XFT: | | XFM: | | XFN: | | XFF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPUU: | | PST: | | PSB: | | PSP: | | PFO: | | PSC: | | PDR: | | AVN: | | AVL: | | AVD: | | PHA: | | PSM: | | MAQ: | | MHC: | | MAD: | | MCA: | | MMT: | | MAH: | | NHL: | | NWA: | | TGR: | | TKM: | | TNI: | | HCH: | | ABO: | | ADI: | | TOL: | | AFE: | | AFR: | | ACU: | | AFI: | | CCX: | | SUR: | | SCL: | | HOH: | | PLA: | | BBT: | | SCH: | | GOX: | | GOH: | | GBE: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | TMO: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BPU: | | BPF: | | BMQ: | | BMD: | | BJS: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | ESI: | | EAT: | | EAN: | | BBE: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | TCO: | | AAC: | | AAD: | | SAY: | | SAP: | | MLB: | | NFA: | | SMA: | | SCB: | | MTS: | | FRI: | | FAL: | | FSY: | | SEN: | | AMI: | | SESP: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | TPX: | | HHY: | | SGN: | | FTE: | | PSL: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYR: | | SYX: | | SYP: | | MAR: | | CYP: | | CYC: | | CYH: | | CYJ: | | CAN: | | CSN: | | CALO: | | CALT: | | RIV: | | PMT: | | PMF: | | GEI: | | ONI: | | MIC: | | ARP: | | CTHE: | | PLP: | | SCS: | | AAE: | | HYA: | | HHO: | | HYS: | | HTH: | | HTE: | | SUL: | | SAF: | | PMX: | | LFC: | | LFI: | | MOX: | |
» show all
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| Reference |
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| Authors |
Furfine ES, Abeles RH. |
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| Title |
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae. |
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| Journal |
J. Biol. Chem. 263 (1988) 9598-606. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Reference |
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| Authors |
Wray JW, Abeles RH. |
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| Title |
The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases. |
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| Journal |
J. Biol. Chem. 270 (1995) 3147-53. |
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| Organism |
Klebsiella pneumoniae [GN: kpn] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 1114239-22-3 |
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