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Entry
EC 4.2.1.118                Enzyme                                 

Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = protocatechuate + H2O [RN:R01627]
Reaction(KEGG)
Substrate
3-dehydro-shikimate
Product
protocatechuate [CPD:C00230];
H2O [CPD:C00001]
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K09483  
3-dehydroshikimate dehydratase
K15652  
3-dehydroshikimate dehydratase
Genes
PAO: 
XSA: 
PPG: 
PPW: 
PPUT: 
PPUN: 
PP4_12570(quiC)
PSV: 
PPV: 
ACB: 
ABM: 
ABSDF2013(quiC)
ABY: 
ABAYE1683(quiC)
ABC: 
ABN: 
ABB: 
ABX: 
ABZ: 
ABR: 
ABD: 
ABH: 
ABAD: 
ABJ: 
ABAB: 
ABAJ: 
ABAZ: 
ABK: 
ABAU: 
ABAA: 
ABW: 
ABAL: 
ACC: 
ANO: 
ACD: 
ACI: 
ACIAD1714(quiC)
AJO: 
ACW: 
MAQ: 
MHC: 
AMAC: 
AMG: 
ASP: 
AAW: 
OAI: 
OCE: 
AMIM: 
AAK: 
SFH: 
RPA: 
RPT: 
RPX: 
NWI: 
MEX: 
MEA: 
MDI: 
MCH: 
MPO: 
META: 
AUA: 
PGA: 
PGL: 
PGD: 
LMD: 
ALI: 
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
BAMN: 
BAMB: 
BAMT: 
BAMY: 
BMP: 
BAO: 
BAMF_0287(RBAM_003390)
BAZ: 
BQL: 
LL3_00296(prot)
BXH: 
BQY: 
BAMI: 
BAMC: 
BAMF: 
BAE: 
BATR: 
BAN: 
BAR: 
GBAA_1986(asbF)
BAT: 
BAH: 
BAI: 
BAA_2054(asbF)
BAX: 
BANT: 
BANR: 
BANS: 
BANH: 
BANV: 
DJ46_791(asbF)
BAL: 
BCE: 
BCZ: 
BCB: 
BCU: 
BCG: 
BCX: 
BCA_2048(asbF)
BCF: 
BCEF: 
BTK: 
BTL: 
BTB: 
BTT: 
BTHR: 
BTHI: 
BTC: 
BTM: 
MC28_1189(asbF)
BTG: 
BTI: 
BTN: 
BTHT: 
BTHU: 
BTW: 
BF38_3200(asbF)
BWE: 
BWW: 
bwei_3030(asbF)
BTY: 
BMYO: 
BG05_4000(asbF)
BCL: 
BPF: 
BLE: 
BACP: 
BACB: 
BBY: 
BON: 
LSP: 
LFU: 
EXM: 
BBE: 
BLR: 
PMS: 
PMQ: 
PMW: 
AAC: 
AAD: 
AUI: 
LMOI: 
 » show all
Taxonomy
Reference
1  [PMID:18975921]
  Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
  Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
  Journal
Biochemistry. 47 (2008) 12251-3.
Reference
2  [PMID:18955706]
  Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
  Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 17133-8.
  Sequence
[ban:BA_1986]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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