KEGG   ENZYME: 4.2.1.118Help
Entry
EC 4.2.1.118                Enzyme                                 
Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = protocatechuate + H2O [RN:R01627]
Reaction(KEGG)
Substrate
3-dehydro-shikimate
Product
protocatechuate [CPD:C00230];
H2O [CPD:C00001]
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Orthology
K09483  
3-dehydroshikimate dehydratase
K15652  
3-dehydroshikimate dehydratase
Genes
PAO: 
PPG: 
PPW: 
ACI: 
ACIAD1714(quiC)
ACD: 
ACB: 
ABM: 
ABSDF2013(quiC)
ABY: 
ABAYE1683(quiC)
ABC: 
ABN: 
ABB: 
ABBFA_001571
MAQ: 
Maqu_3527
MHC: 
MARHY3427
AMAC: 
MASE_09730
AMG: 
AMEC673_09975
OCE: 
GU3_03580
SFH: 
SFHH103_01320
RPA: 
RPA2386
RPT: 
Rpal_2628
RPX: 
Rpdx1_3185
NWI: 
Nwi_2298
MEX: 
Mext_3763
MEA: 
Mex_1p4135
MDI: 
METDI4727
MCH: 
Mchl_4058
MPO: 
Mpop_4019
PGA: 
PGA1_78p00450
PGL: 
PGA2_95p540
ALI: 
AZOLI_p20608
BAO: 
BAMF_0287(RBAM_003390)
BAY: 
RBAM_003390
BAQ: 
BACAU_0282
BYA: 
BANAU_0281(asbF)
BAMP: 
B938_01450
BAML: 
BAM5036_0298
BAZ: 
BAMTA208_01445
BQL: 
LL3_00296(prot)
BXH: 
BAXH7_00299
BQY: 
MUS_0297
BAMI: 
KSO_017965
BAE: 
BATR1942_20215
BAN: 
BA_1986
BAR: 
GBAA_1986
BAT: 
BAS1843
BAH: 
BAMEG_2604(asbF)
BAI: 
BAA_2054(asbF)
BAX: 
H9401_1883
BAL: 
BACI_c19600
BCE: 
BC1983
BCZ: 
BCZK1800
BCB: 
BCB4264_A1988(asbF)
BCU: 
BCAH820_2021(asbF)
BCG: 
BCG9842_B3341(asbF)
BCX: 
BCA_2048(asbF)
BCF: 
bcf_09775
BTK: 
BT9727_1817
BTL: 
BALH_1758
BTB: 
BMB171_C1770(asbF)
BTT: 
HD73_2152
BTC: 
CT43_CH1939(asbF)
BTM: 
MC28_1189
BTG: 
BTB_c20530(asbF)
BTI: 
BTG_10030
BTN: 
BTF1_07305
BTHT: 
H175_ch1965
BWE: 
BcerKBAB4_1849
BCL: 
ABC1952
BPF: 
BpOF4_08950
LSP: 
Bsph_2958
BBE: 
BBR47_20500
PMS: 
KNP414_07050(asbF)
PMQ: 
PM3016_6640
PMW: 
B2K_33545
AAC: 
Aaci_2516
AAD: 
TC41_2813
 » show all
Taxonomy
Reference
1  [PMID:18975921]
  Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
  Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
  Journal
Biochemistry. 47 (2008) 12251-3.
  Organism
Bacillus thuringiensis
Reference
2  [PMID:18955706]
  Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
  Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 17133-8.
  Organism
Bacillus anthracis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system