KEGG   ENZYME: 4.2.1.123Help
Entry
EC 4.2.1.123                Enzyme                                 

Name
tetrahymanol synthase;
squalene-tetrahymanol cyclase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
squalene hydro-lyase (tetrahymanol forming)
Reaction(IUBMB)
tetrahymanol = squalene + H2O [RN:R02875]
Reaction(KEGG)
Substrate
tetrahymanol [CPD:C06083]
Product
squalene [CPD:C00751];
H2O [CPD:C00001]
Comment
The reaction occurs in the reverse direction.
History
EC 4.2.1.123 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Reference
1  [PMID:1892870]
  Authors
Saar J, Kader JC, Poralla K, Ourisson G
  Title
Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila.
  Journal
Biochim. Biophys. Acta. 1075 (1991) 93-101.
Reference
2  [PMID:15959594]
  Authors
Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D
  Title
Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis.
  Journal
Chem. Commun. (Camb).  (2005) 3089-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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