| Entry |
|
| Name |
N-acetylmuramic acid 6-phosphate etherase;
MurNAc-6-P etherase;
MurQ
|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
 |
| Sysname |
(R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming)
|
| Reaction(IUBMB) |
(R)-lactate + N-acetyl-D-glucosamine 6-phosphate = N-acetylmuramate 6-phosphate + H2O [RN: R08555]
|
| Reaction(KEGG) |
|
| Substrate |
(R)-lactate [CPD: C00256];
N-acetyl-D-glucosamine 6-phosphate [CPD: C00357]
|
| Product |
|
| Comment |
This enzyme, along with EC 2.7.1.170, anhydro-N-acetylmuramic acid kinase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling.
|
| Pathway |
| Amino sugar and nucleotide sugar metabolism |
|
| Orthology |
| N-acetylmuramic acid 6-phosphate etherase |
|
| Genes |
NHE: | | NFI: | | AFM: | | AOR: | | AFV: | | ACT: | | PCS: | | CIM: | | ABE: | | TVE: | | MPR: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | EBF: | | HIN: | | HAP: | | HPR: | | HSO: | | HSM: | | PMU: | | PMV: | | PUL: | | PMP: | | MSU: | | MHT: | | MHQ: | | MHX: | | APL: | | APJ: | | APA: | | ASU: | | ASI: | | AAP: | | AAT: | | AAO: | | AAN: | | GAN: | | BTO: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | CPS: | | PAT: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | GPS: | | PIN: | | PSY: | | FTU: | | FTF: | | FTW: | | FTR: | | FTT: | | FTG: | | FTL: | | FTH: | | FTA: | | FTS: | | FTI: | | FTM: | | FTN: | | FCF: | | FCN: | | FPH: | | FRT: | | FNA: | | AHA: | | OCE: | | SAGA: | | BUR: | | ADE: | | ACP: | | ANK: | | MSD: | | CCX: | | SUR: | | HOH: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ARA: | | RTR: | | OAN: | | MEX: | | MEA: | | MDI: | | MCH: | | MET: | | MPO: | | MNO: | | RVA: | | PHL: | | MSC: | | SIL: | | SIT: | | JAN: | | PDE: | | KVU: | | KVL: | | PSF: | | PGA: | | PGL: | | ZMO: | | ZMN: | | ZMM: | | ZMB: | | ZMP: | | GOX: | | GOH: | | GDI: | | GDJ: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | AZL: | | ALI: | | APB: | | MAI: | | MAN: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BHA: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BCL: | | BPU: | | BPF: | | BMQ: | | BMD: | | BMH: | | BSE: | | BCK: | | BAG: | | OIH: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GMC: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SEP: | | SER: | | SHA: | | SSP: | | SCA: | | SLG: | | SLN: | | SWA: | | LMF: | | LMC: | | LMP: | | LMW: | | LMZ: | | LMON: | | LMOO: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LWE: | | LSG: | | LIV: | | LSP: | | HHD: | | ESI: | | EAT: | | EAN: | | BBE: | | GYM: | | SIV: | | LLA: | | LLK: | | LLT: | | LLS: | | LLC: | | LLM: | | LLR: | | LLN: | | LLI: | | LGR: | | LGV: | | SSU: | | SSV: | | SSB: | | SSI: | | SSS: | | SSF: | | SSW: | | SUI: | | SUO: | | SUP: | | SSUS: | | SIE: | | LPL: | | LPJ: | | LPT: | | LPS: | | LJO: | | LJF: | | LJH: | | LAC: | | LBR: | | LBK: | | LCA: | | LCB: | | LCZ: | | LCS: | | LCE: | | LGA: | | LHL: | | LHR: | | LRH: | | LRG: | | LRL: | | LRA: | | LCR: | | LKE: | | PPE: | | PCE: | | EFA: | | EFL: | | EFI: | | EFD: | | EFS: | | EFC: | | EFU: | | EFM: | | EHR: | | ENE: | | ECAS: | | MPX: | | THL: | | OOE: | | CRN: | | CML: | | CAC: | | CAE: | | CAY: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBF: | | CBM: | | CBE: | | CPY: | | CSH: | | CDF: | | CDC: | | CDL: | | CDG: | | AMT: | | STH: | | APR: | | FPR: | | FPA: | | SAY: | | SAP: | | TTE: | | TEX: | | THX: | | TMT: | | TEP: | | TAE: | | TOC: | | TTM: | | TTO: | | TSH: | | SSG: | | SRI: | | MED: | | MHG: | | AFN: | | AIN: | | ERH: | | MMY: | | MMYM: | | MML: | | MCD: | | MLC: | | MLH: | | MCY: | | ACL: | | MSM: | | MSG: | | NBR: | | RER: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | LXX: | | AAU: | | ARR: | | RSA: | | BCV: | | BFA: | | PAC: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | PACH: | | PBO: | | PRA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | AMI: | | SESP: | | MAU: | | MIL: | | ASE: | | CAI: | | SNA: | | RXY: | | APV: | | SSM: | | BHY: | | BIP: | | SBU: | | SGP: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | BTH: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | BXY: | | PGI: | | PGN: | | PGT: | | PDI: | | PPN: | | TFO: | | PRU: | | PDT: | | AFD: | | ASH: | | SRU: | | SRM: | | RMR: | | RMG: | | CPI: | | NKO: | | PHE: | | PSN: | | SHG: | | SCN: | | HHY: | | CMR: | | BBD: | | EVI: | | CHU: | | DFE: | | SLI: | | LBY: | | RSI: | | FLI: | | EOL: | | FAE: | | MTT: | | GFO: | | FJO: | | FPS: | | FBR: | | FCO: | | FIN: | | CCM: | | RBI: | | ZPR: | | CAT: | | FBC: | | CAO: | | CLY: | | KDI: | | LAN: | | ZGA: | | MRS: | | ASL: | | PTQ: | | NDO: | | POM: | | FTE: | | OHO: | | STR: | | SMF: | | GAU: | | RBA: | | IPA: | | SACI: | | EMI: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYW: | | SYC: | | SYF: | | SYD: | | SYE: | | SYG: | | SYR: | | SYX: | | SYP: | | CYB: | | SYNE: | | SYNP: | | TEL: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CGC: | | CAN: | | CSN: | | DSL: | | HAO: | | GLP: | | CMP: | | CYU: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMA: | | PMT: | | PMN: | | PMF: | | PMJ: | | PME: | | TER: | | LEP: | | GEI: | | OAC: | | ONI: | | PSEU: | | CEP: | | MIC: | | ARP: | | CTHE: | | PLP: | | SCS: | | IAL: | | TRO: | | CAP: | | DRA: | | DGE: | | DDR: | | DGO: | | DPD: | | TSC: | | MRB: | | MRE: | | MSV: | | OPR: | | TLE: | | TTA: | | PMO: | | KOL: | | MPG: | | TTR: | | CEX: | | PTO: | | » show all
 |
| Reference |
|
| Authors |
Jaeger T, Arsic M, Mayer C |
| Title |
Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase". |
| Journal |
J. Biol. Chem. 280 (2005) 30100-6. |
| Reference |
|
| Authors |
Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT |
| Title |
Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate. |
| Journal |
J. Bacteriol. 187 (2005) 3643-9. |
| Reference |
|
| Authors |
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT |
| Title |
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. |
| Journal |
J. Bacteriol. 188 (2006) 1660-2. |
| Reference |
|
| Authors |
Hadi T, Dahl U, Mayer C, Tanner ME |
| Title |
Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling. |
| Journal |
Biochemistry. 47 (2008) 11547-58. |
| Reference |
|
| Authors |
Jaeger T, Mayer C |
| Title |
N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism. |
| Journal |
Cell. Mol. Life. Sci. 65 (2008) 928-39. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |