KEGG   ENZYME: 4.2.1.127Help
Entry
EC 4.2.1.127                Enzyme                                 

Name
linalool dehydratase;
linalool hydro-lyase (myrcene-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(3S)-linalool hydro-lyase (myrcene-forming)
Reaction(IUBMB)
(3S)-linalool = myrcene + H2O [RN:R09702]
Reaction(KEGG)
Substrate
(3S)-linalool [CPD:C11389]
Product
myrcene [CPD:C06074];
H2O [CPD:C00001]
Comment
In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the hydration of myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol, the latter activity being classified as EC 5.4.4.4, geraniol isomerase.
History
EC 4.2.1.127 created 2011, modified 2012
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K20614  
linalool dehydratase / geraniol isomerase
Genes
CDN: 
Taxonomy
Reference
1  [PMID:20663876]
  Authors
Brodkorb D, Gottschall M, Marmulla R, Luddeke F, Harder J
  Title
Linalool dehydratase-isomerase, a bifunctional enzyme in the anaerobic degradation of monoterpenes.
  Journal
J. Biol. Chem. 285 (2010) 30436-42.
  Sequence
Reference
2  [PMID:21950166]
  Authors
Luddeke F, Harder J
  Title
Enantiospecific (S)-(+)-linalool formation from beta-myrcene by linalool dehydratase-isomerase.
  Journal
Z. Naturforsch. C. 66 (2011) 409-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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