KEGG   ENZYME: 4.2.1.132Help
Entry
EC 4.2.1.132                Enzyme                                 

Name
2-hydroxyhexa-2,4-dienoate hydratase;
tesE (gene name);
hsaE (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxohexanoate hydro-lyase [(2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming]
Reaction(IUBMB)
4-hydroxy-2-oxohexanoate = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O [RN:R09960]
Reaction(KEGG)
R09960;
(other) R05864
Show
Substrate
4-hydroxy-2-oxohexanoate [CPD:C06762]
Product
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate [CPD:C20240];
H2O [CPD:C00001]
Comment
This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions.
History
EC 4.2.1.132 created 2012
Pathway
Xylene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18364  
2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Genes
PGE: 
PSD: 
PRE: 
PPSE: 
BN5_3620(nahL)
PPUT: 
PPUN: 
PPJ: 
PSC: 
PSTU: 
PBM: 
PPUU: 
PKC: 
PKB_4239(xylJ)
PFZ: 
PALK: 
PPSY: 
AVN: 
AVL: 
AVD: 
ACX: 
SPL: 
SHL: 
SWD: 
PHA: 
PSHAa2141(xylJ)
PTN: 
MAD: 
MSR: 
SPOI: 
ZAL: 
CYQ: 
CZA: 
BLEP: 
AEH: 
APAC: 
GPB: 
TBN: 
RPI: 
RPF: 
RPJ: 
REU: 
REH: 
H16_B0548(mhpD1) H16_B0597(bphH)
CNC: 
RME: 
Rmet_1321(xylJ)
CTI: 
CBW: 
BVI: 
BUR: 
BCJ: 
BCEN: 
DM39_3383(dmpE) DM39_4834(dmpE)
BCEO: 
BCT: 
BCED: 
DM42_4993(dmpE) DM42_6345(dmpE)
BPYR: 
BCON: 
BUQ: 
BXE: 
Bxe_C1189(bphH)
BXB: 
DR64_8616(dmpE)
BFN: 
OI25_4589(dmpE)
PPK: 
PRB: 
PVE: 
CDN: 
PNA: 
AJS: 
VEI: 
CTT: 
CTES: 
ADN: 
ADK: 
MPT: 
JAG: 
GJA_236(xylJ)
MASW: 
LCH: 
AZO: 
azo1853(lapE) azo2434(nahL)
AZI: 
DAR: 
TMZ: 
THU: 
RBU: 
ARC: 
NAR: 
NPP: 
NPN: 
SPHM: 
SSAN: 
SJP: 
SYB: 
 » show all
Taxonomy
Reference
1  [PMID:16151114]
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl. Environ. Microbiol. 71 (2005) 5275-81.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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