KEGG   ENZYME: 4.2.1.133Help
Entry
EC 4.2.1.133                Enzyme                                 

Name
copal-8-ol diphosphate hydratase;
CcCLS
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate hydro-lyase [(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate forming]
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O [RN:R09967]
Reaction(KEGG)
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270]
Product
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Comment
Requires Mg2+. The enzyme was characterized from the plant Cistus creticus subsp. creticus.
History
EC 4.2.1.133 created 2012
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K20516  
copal-8-ol diphosphate hydratase
K20518  
copal-8-ol diphosphate hydratase / cis-abienol synthase
Reference
1  [PMID:20595348]
  Authors
Falara V, Pichersky E, Kanellis AK
  Title
A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active,  oxygen-containing labdane-type diterpenes.
  Journal
Plant. Physiol. 154 (2010) 301-10.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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