KEGG   ENZYME: 4.2.1.135Help
Entry
EC 4.2.1.135                Enzyme                                 

Name
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining);
PglF
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine hydro-lyase (configuration-retaining; UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose-forming)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O [RN:R10266]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD:C04613];
H2O [CPD:C00001]
Comment
Contains NAD+ as a cofactor [2]. This is the first enzyme in the biosynthetic pathway of N,N'-diacetylbacillosamine [1], the first carbohydrate in the glycoprotein N-linked heptasaccharide in Campylobacter jejuni. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes.
History
EC 4.2.1.135 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K15912  UDP-N-acetyl-D-glucosamine 4,6-dehydratase
Genes
WSU: WS0036(PGLF)
SKU: Sulku_2414
CJE: Cj1120c(pglF)
CJB: BN148_1120c(pglF)
CJJ: CJJ81176_1138(pglF)
CJU: C8J_1061(wlaL)
CJN: ICDCCJ07001_1076
CJI: CJSA_1062(pglF)
CJM: CJM1_1099(pglF)
CJS: CJS3_1167
CJEJ: N564_01088
CJEU: N565_01131
CJEN: N755_01124
CJEI: N135_01157
CJER: H730_06575
CJV: MTVDSCj20_1124(pglF)
CJY: QZ67_01197(pglF)
CJQ: UC78_1078(pglF)
CJR: CJE1263(pglF)
CFT: CFF04554_1370(pglF)
CFV: CFVI03293_1393(pglF)
CFX: CFV97608_1493(pglF)
CFZ: CSG_14930
CAMP: CFT03427_1318(pglF)
CCV: CCV52592_1202(pglF)
CCO: CCC13826_0447(pglF)
CCOC: CCON33237_1460(pglF)
CLA: Cla_1258(pglF)
CLR: UPTC16701_1241(pglF)
CLM: UPTC16712_1259(pglF)
CLQ: UPTC4110_1243(pglF)
CLN: UPTC3659_1478(pglF)
CLL: CONCH_1209(pglF)
CCQ: N149_1062
CCF: YSQ_03365
CCY: YSS_06070
CCOI: YSU_03400
CCOF: VC76_05500(pglF)
CCOO: ATE51_01362(pglF)
CAJ: CIG1485E_1365(pglF)
CIS: CINS_1223(pglF)
CVO: CVOL_1237(pglF)
CPEL: CPEL_1364(pglF)
CAMR: CAQ16704_1269(pglF)
CSM: CSUB8521_1445(pglF)
CSF: CSUB8523_1541(pglF)
CGRA: CGRAC_1485(pglF)
CURE: CUREO_1368(pglF)
CHYO: CHH_1359(pglF)
CHV: CHELV3228_0575(pglF)
CSPF: CSF_1366(pglF)
CPIN: CPIN18020_1228(pglF)
CCUN: CCUN_1176(pglF)
CLX: CLAN_1155(pglF)
 » show all
Taxonomy
Reference
1  [PMID:16286454]
  Authors
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM
  Title
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
  Journal
J. Biol. Chem. 281 (2006) 723-32.
  Sequence
[cje:Cj1120c]
Reference
2  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry. 45 (2006) 13659-69.
  Sequence
[cje:Cj1120c]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.135
IUBMB Enzyme Nomenclature: 4.2.1.135
ExPASy - ENZYME nomenclature database: 4.2.1.135
BRENDA, the Enzyme Database: 4.2.1.135

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