KEGG   ENZYME: 4.2.1.135Help
Entry
EC 4.2.1.135                Enzyme                                 

Name
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining);
PglF
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine hydro-lyase (configuration-retaining; UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose-forming)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O [RN:R10266]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose [CPD:C04613];
H2O [CPD:C00001]
Comment
Contains NAD+ as a cofactor [2]. This is the first enzyme in the biosynthetic pathway of N,N'-diacetylbacillosamine [1], the first carbohydrate in the glycoprotein N-linked heptasaccharide in Campylobacter jejuni. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes.
History
EC 4.2.1.135 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K15912  
UDP-N-acetyl-D-glucosamine 4,6-dehydratase
Genes
WSU: 
WS0036(PGLF)
SKU: 
CJE: 
Cj1120c(pglF)
CJB: 
CJJ: 
CJU: 
C8J_1061(wlaL)
CJN: 
CJI: 
CJSA_1062(pglF)
CJM: 
CJM1_1099(pglF)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
CJQ: 
UC78_1078(pglF)
CJL: 
CJW: 
CJR: 
CJE1263(pglF)
CJZ: 
CJX: 
CFF: 
CFT: 
CFV: 
CFX: 
CFZ: 
CAMP: 
CFP: 
CCV: 
CHA: 
CCO: 
CLA: 
Cla_1258(pglF)
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CAJ: 
CIS: 
CINS_1223(pglF)
CVO: 
CVOL_1237(pglF)
CPEL: 
CPEL_1364(pglF)
CAMR: 
CSM: 
CSF: 
CGRA: 
CURE: 
 » show all
Taxonomy
Reference
1  [PMID:16286454]
  Authors
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM
  Title
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
  Journal
J. Biol. Chem. 281 (2006) 723-32.
  Sequence
[cje:Cj1120c]
Reference
2  [PMID:17087520]
  Authors
Olivier NB, Chen MM, Behr JR, Imperiali B
  Title
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
  Journal
Biochemistry. 45 (2006) 13659-69.
  Sequence
[cje:Cj1120c]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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