KEGG   ENZYME: 4.2.1.139Help
Entry
EC 4.2.1.139                Enzyme                                 

Name
medicarpin synthase;
medicarpan synthase;
7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase;
2',7-dihydroxy-4'-methoxyisoflavanol dehydratase;
DMI dehydratase;
DMID
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
4'-methoxyisoflavan-2',4,7-triol hydro-lyase [(-)-medicarpin-forming]
Reaction(IUBMB)
4'-methoxyisoflavan-2',4,7-triol = (-)-medicarpin + H2O [RN:R07738]
Reaction(KEGG)
Substrate
4'-methoxyisoflavan-2',4,7-triol
Product
(-)-medicarpin [CPD:C10503];
H2O [CPD:C00001]
Comment
Isolated from the plant Medicago sativa (alfalfa). Catalyses the final step in the biosynthesis of medicarpin, the main pterocarpan phytoalexin in alfalfa.
History
EC 4.2.1.139 created 2013
Pathway
ec00943  Isoflavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:7805842]
  Authors
Guo L, Dixon RA, Paiva NL
  Title
The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone  reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis.
  Journal
FEBS. Lett. 356 (1994) 221-5.
Reference
2  [PMID:8071365]
  Authors
Guo L, Dixon RA, Paiva NL.
  Title
Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2'-dihydroxy-4'-methoxyisoflavanol  dehydratase.
  Journal
J. Biol. Chem. 269 (1994) 22372-8.
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.139
IUBMB Enzyme Nomenclature: 4.2.1.139
ExPASy - ENZYME nomenclature database: 4.2.1.139
BRENDA, the Enzyme Database: 4.2.1.139

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