KEGG   ENZYME: 4.2.1.141Help
Entry
EC 4.2.1.141                Enzyme                                 

Name
2-dehydro-3-deoxy-D-arabinonate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-D-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O [RN:R09186]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-D-arabinonate [CPD:C03826]
Product
2,5-dioxopentanoate [CPD:C00433];
H2O [CPD:C00001]
Comment
The enzyme participates in pentose oxidation pathways that convert pentose sugars to the tricarboxylic acid cycle intermediate 2-oxoglutarate.
History
EC 4.2.1.141 created 2013
Pathway
Pentose and glucuronate interconversions
Orthology
K14259  
2-dehydro-3-deoxy-D-arabinonate dehydratase
Genes
PSU: 
PSUW: 
SCL: 
sce8243(faa)
SCU: 
BCL: 
BMEG: 
BEO: 
GKA: 
GTN: 
GCT: 
GJF: 
GYM: 
PMS: 
PMQ: 
PMW: 
PNP: 
TCO: 
SVL: 
SBH: 
SRC: 
BCV: 
KFL: 
GOB: 
BSD: 
AMD: 
AMN: 
AMM: 
AMZ: 
KPHY: 
AMS: 
AFS: 
RXY: 
TRO: 
CAP: 
DPD: 
FGI: 
TTR: 
OTE: 
ACA: 
TRS: 
SUS: 
RBA: 
RB8851(hpaG)
PSL: 
PLM: 
PBS: 
IPA: 
SACI: 
NKO: 
HHY: 
SHG: 
CMR: 
CAMU: 
DFE: 
SLI: 
SRD: 
LBY: 
RSI: 
EOL: 
FAE: 
RBI: 
FBC: 
HHB: 
HMA: 
HHI: 
HHN: 
HAB: 
HLA: 
HVO: 
HGI: 
HTU: 
HXA: 
NOU: 
HLR: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
CMA: 
VMO: 
CSU: 
 » show all
Taxonomy
Reference
1  [PMID:16849334]
  Authors
Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J
  Title
Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.
  Journal
J. Biol. Chem. 281 (2006) 27378-88.
  Sequence
[sso:SSO3118]
Reference
2  [PMID:18448118]
  Authors
Brouns SJ, Barends TR, Worm P, Akerboom J, Turnbull AP, Salmon L, van der Oost J
  Title
Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features  of the FAH superfamily.
  Journal
J. Mol. Biol. 379 (2008) 357-71.
  Sequence
[sso:SSO3118]
Reference
3  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P.
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J. Biol. Chem. 284 (2009) 27290-303.
  Sequence
[hvo:HVO_B0027]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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