KEGG   ENZYME: 4.2.1.142Help
Entry
EC 4.2.1.142                Enzyme                                 

Name
5'-oxoaverantin cyclase;
OAVN cyclase;
5'-oxoaverantin hydro-lyase [(2'S,5'S)-averufin forming]
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
5'-oxoaverantin hydro-lyase [(1'S,5'S)-averufin forming]
Reaction(IUBMB)
5'-oxoaverantin = (1'S,5'S)-averufin + H2O [RN:R10475]
Reaction(KEGG)
Substrate
5'-oxoaverantin [CPD:C20502]
Product
(1'S,5'S)-averufin [CPD:C20574];
H2O [CPD:C00001]
Comment
Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis.
History
EC 4.2.1.142 created 2013
Pathway
Aflatoxin biosynthesis
Orthology
K17646  
5'-oxoaverantin cyclase / versicolorin B synthase
Genes
PAN: 
ANI: 
AOR: 
AOR_1_60014(AO090026000028)
AFV: 
Taxonomy
Reference
1  [PMID:14602595]
  Authors
Sakuno E, Yabe K, Nakajima H
  Title
Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin biosynthesis.
  Journal
Appl. Environ. Microbiol. 69 (2003) 6418-26.
  Sequence
Reference
2  [PMID:15932995]
  Authors
Sakuno E, Wen Y, Hatabayashi H, Arai H, Aoki C, Yabe K, Nakajima H
  Title
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
  Journal
Appl. Environ. Microbiol. 71 (2005) 2999-3006.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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