KEGG   ENZYME: 4.2.1.145Help
Entry
EC 4.2.1.145                Enzyme                                 

Name
capreomycidine synthase;
VioD (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(2S,3S)-3-hydroxyarginine hydro-lyase (cyclizing, (2S,3R)-capreomycidine-forming)
Reaction(IUBMB)
(2S,3S)-3-hydroxyarginine = (2S,3R)-capreomycidine + H2O [RN:R09364]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxyarginine [CPD:C18473]
Product
(2S,3R)-capreomycidine [CPD:C18472];
H2O [CPD:C00001]
Comment
A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin.
History
EC 4.2.1.145 created 2013
Orthology
K20615  
capreomycidine synthase
Reference
1  [PMID:15368581]
  Authors
Yin X, McPhail KL, Kim KJ, Zabriskie TM
  Title
Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway.
  Journal
Chembiochem. 5 (2004) 1278-81.
Reference
2  [PMID:15368582]
  Authors
Ju J, Ozanick SG, Shen B, Thomas MG.
  Title
Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861.
  Journal
Chembiochem. 5 (2004) 1281-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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