KEGG   ENZYME: 4.2.1.148Help
Entry
EC 4.2.1.148                Enzyme                                 

Name
2-methylfumaryl-CoA hydratase;
Mcd;
erythro-beta-methylmalonyl-CoA hydrolyase;
mesaconyl-coenzyme A hydratase (ambiguous);
mesaconyl-C1-CoA hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming)
Reaction(IUBMB)
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O [RN:R05076]
Reaction(KEGG)
Substrate
(2R,3S)-2-methylmalyl-CoA [CPD:C06027]
Product
2-methylfumaryl-CoA [CPD:C06028];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 4.2.1.148 created 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14449  2-methylfumaryl-CoA hydratase
Genes
KAK: Kalk_01780
KKO: Kkor_1561
KGE: TQ33_0883
KSD: KS2013_924
KPD: CW740_07365
GPB: HDN1F_16000(maoC)
RPJ: N234_23790
REU: Reut_B4149
REH: H16_B0354(h16_B0354)
RME: Rmet_4428
MMB: Mmol_0752
MEH: M301_0690
GCA: Galf_0005
ABU: Abu_1926
ABT: ABED_1735
ARC: ABLL_2357
SCL: sce0588
PLA: Plav_1430
BOS: BSY19_19
XAU: Xaut_1970
AZC: AZC_3739(maoC)
MEX: Mext_3781
MEA: Mex_1p4153(meaC)
MDI: METDI4744(mcd)
MCH: Mchl_4075
MET: M446_3940
MPO: Mpop_4037
MNO: Mnod_3627
MOR: MOC_5123
META: Y590_18780
MAQU: Maq22A_c24130(meaC)
HDN: Hden_3241
HMC: HYPMC_4595(meaC)
RVA: Rvan_0096
BVR: BVIR_2665
MSC: BN69_0351
MCG: GL4_0095
HDI: HDIA_0200
RBM: TEF_04290
CCR: CC_3656
CAK: Caul_5003
CSE: Cseg_4148
SIL: SPO0355
RSP: RSP_0973
RCP: RCAP_rcc00730(maoC)
JAN: Jann_0813
RDE: RD1_1623
PDE: Pden_0566
DSH: Dshi_2871
PSF: PSE_4924
PGD: Gal_03131
OTM: OSB_04790
CID: P73_3865
MALG: MALG_02742
RSU: NHU_00727(maoC)
RHC: RGUI_0619
SPSE: SULPSESMR1_00397(mch)
RMM: ROSMUCSMR3_02502(mch)
AHT: ANTHELSMS3_02130(mch)
HNE: HNE_3531
HBA: Hbal_0271
RRU: Rru_A1201
RRF: F11_06220
MAGX: XM1_1405
MAGN: WV31_15110
TMO: TMO_3272
TXI: TH3_18445
MAGQ: MGMAQ_3595
PSIM: KR76_08755
RCA: Rcas_0913
CAU: Caur_0173
CAG: Cagg_1326
LIL: LA_2627
LIE: LIF_A2151
LIC: LIC_11359(maoC)
LIS: LIL_11480
LBJ: LBJ_1640(maoC)
LBL: LBL_1859(maoC)
LBF: LBF_0760(maoC)
LST: LSS_02729
HMA: rrnAC0688
HHI: HAH_1340
HMU: Hmuk_2983
HTU: Htur_1591
NMG: Nmag_3337
NAT: NJ7G_3290
SALI: L593_04665
VDI: Vdis_0232
 » show all
Taxonomy
Reference
1  [PMID:18065535]
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G.
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J. Bacteriol. 190 (2008) 1366-74.
  Sequence
[cau:Caur_0173][rsp:RSP_0973]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.148
IUBMB Enzyme Nomenclature: 4.2.1.148
ExPASy - ENZYME nomenclature database: 4.2.1.148
BRENDA, the Enzyme Database: 4.2.1.148

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