KEGG   ENZYME: 4.2.1.148Help
Entry
EC 4.2.1.148                Enzyme                                 

Name
2-methylfumaryl-CoA hydratase;
Mcd;
erythro-beta-methylmalonyl-CoA hydrolyase;
mesaconyl-coenzyme A hydratase (ambiguous);
mesaconyl-C1-CoA hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming)
Reaction(IUBMB)
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O [RN:R05076]
Reaction(KEGG)
Substrate
(2R,3S)-2-methylmalyl-CoA [CPD:C06027]
Product
2-methylfumaryl-CoA [CPD:C06028];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 4.2.1.148 created 2014
Pathway
Glyoxylate and dicarboxylate metabolism
C5-Branched dibasic acid metabolism
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14449  
2-methylfumaryl-CoA hydratase
Genes
KKO: 
KGE: 
GPB: 
RPJ: 
REU: 
REH: 
H16_B0354(h16_B0354)
RME: 
AXY: 
MMB: 
MEH: 
MBAC: 
MEU: 
APP: 
GCA: 
BEB: 
ABU: 
ABT: 
ABL: 
ANT: 
ARC: 
SCL: 
SCU: 
HOE: 
PLA: 
BOP: 
XAU: 
AZC: 
AZC_3739(maoC)
MEX: 
MEA: 
MDI: 
MCH: 
MRD: 
MET: 
MPO: 
MNO: 
MOR: 
META: 
MAQU: 
CHEL: 
HDN: 
HDT: 
HMC: 
HNI: 
RVA: 
FIL: 
FIY: 
BVR: 
RHZ: 
MSC: 
MCG: 
CCR: 
CCS: 
CAK: 
CSE: 
CHQ: 
SIL: 
SIT: 
RSP: 
RSH: 
RSQ: 
RSK: 
RCP: 
JAN: 
RDE: 
RLI: 
PDE: 
PAMI: 
DSH: 
PSF: 
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
OTM: 
LMD: 
RED: 
PTP: 
CID: 
CMAR: 
MALG: 
CON: 
RSU: 
NHU_00727(maoC)
PPHR: 
HAT: 
LAP: 
HNE: 
HBA: 
HBC: 
RRU: 
RRF: 
RPM: 
MGY: 
MAGX: 
TMO: 
TXI: 
MAGQ: 
PGV: 
ARS: 
PSIM: 
AER: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
LIL: 
LIE: 
LIC: 
LIC_11359(maoC)
LIS: 
LBJ: 
LBJ_1640(maoC)
LBL: 
LBL_1859(maoC)
LBI: 
LBF: 
LBF_0760(maoC)
LST: 
TPX: 
HMA: 
HHI: 
HHN: 
HAB: 
HMU: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
VDI: 
 » show all
Taxonomy
Reference
1  [PMID:18065535]
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G.
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J. Bacteriol. 190 (2008) 1366-74.
  Sequence
[cau:Caur_0173][rsp:RSP_0973]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system