KEGG   ENZYME: 4.2.1.158Help
Entry
EC 4.2.1.158                Enzyme                                 

Name
galactarate dehydratase (D-threo-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
galactarate hydro-lyase (3-deoxy-D-threo-hex-2-ulosarate-forming)
Reaction(IUBMB)
galactarate = (2S,3R)-2,3-dihydroxy-5-oxohexanedioate + H2O [RN:R11077]
Reaction(KEGG)
Substrate
galactarate [CPD:C00879]
Product
(2S,3R)-2,3-dihydroxy-5-oxohexanedioate [CPD:C21091];
H2O [CPD:C00001]
Comment
The enzyme has been characterized from the bacterium Oceanobacillus iheyensis. cf. EC 4.2.1.42, galactarate dehydratase.
History
EC 4.2.1.158 created 2015
Orthology
K20022  galactarate dehydratase (D-threo-forming)
Genes
BCL: ABC3013
OIH: OB2843
PMS: KNP414_06295
PMQ: PM3016_5909
PMW: B2K_30050
Taxonomy
Reference
1  [PMID:19883118]
  Authors
Rakus JF, Kalyanaraman C, Fedorov AA, Fedorov EV, Mills-Groninger FP, Toro R, Bonanno J, Bain K, Sauder JM, Burley SK, Almo SC, Jacobson MP, Gerlt JA
  Title
Computation-facilitated assignment of the function in the enolase superfamily: a  regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .
  Journal
Biochemistry. 48 (2009) 11546-58.
  Sequence
[oih:OB2843]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.158
IUBMB Enzyme Nomenclature: 4.2.1.158
ExPASy - ENZYME nomenclature database: 4.2.1.158
BRENDA, the Enzyme Database: 4.2.1.158

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