KEGG   ENZYME: 4.2.1.18Help
Entry
EC 4.2.1.18                 Enzyme                                 
Name methylglutaconyl-CoA hydratase;
methylglutaconyl coenzyme A hydratase;
3-methylglutaconyl CoA hydratase;
methylglutaconase;
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
Class Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
(trans-3-methylglutaconyl-CoA-forming)
Reaction(IUBMB) (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA +
H2O [RN:R02085]
Reaction(KEGG) R02085
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Substrate (S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356]
Product trans-3-methylglutaconyl-CoA [CPD:C03231];
H2O [CPD:C00001]
Pathway ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
Orthology K05607  methylglutaconyl-CoA hydratase
K13766  methylglutaconyl-CoA hydratase
Genes HSA: 549(AUH)
PTR: 464587(AUH) 470410
MCC: 704542(AUH)
MMU: 11992(Auh)
RNO: 361215(Auh)
CFA: 476348(AUH)
ECB: 100064392
MDO: 100028211
TGU: 100231431
XLA: 734576(auh)
XTR: 548406(auh)
DRE: 445182(auh)
BFO: BRAFLDRAFT_119346
SPU: 577505
AFM: AFUA_3G11480
UMA: UM01935.1
XCC: XCC1833
XCB: XC_2356
XCA: xccb100_2121
XCV: XCV1899
XAC: XAC1853
XOO: XOO2901
XOM: XOO_2751
XOP: PXO_00100
XAL: XALc_1333
SML: Smlt2209
SMT: Smal_1802
VVU: VV2_0498
VVY: VVA1048
VPA: VPA0616
VHA: VIBHAR_05478
VEX: VEA_000379 VEA_001541
PAE: PA2013(liuC)
PAU: PA14_38470(gnyH)
PAP: PSPA7_3276
PAG: PLES_33101(liuC)
PPU: PP_4066
PPF: Pput_1775
PPG: PputGB1_3664
PPW: PputW619_1810
PST: PSPTO_2737
PSB: Psyr_2468
PSP: PSPPH_2626
PFL: PFL_3938(echA7)
PFO: Pfl01_3658
PFS: PFLU3891
PEN: PSEEN3388
PMY: Pmen_2031
PSA: PST_3215
AVN: Avin_49530
PAR: Psyc_0310
PCR: Pcryo_0341
PRW: PsycPRwf_2066
ACD: AOLE_11855
ABY: ABAYE2290(mgh)
ABC: ACICU_01409
ABN: AB57_1599
ABB: ABBFA_002120
SON: SO_1895
SDN: Sden_2247
SFR: Sfri_2729
SAZ: Sama_1360
SBL: Sbal_2830
SBM: Shew185_2848
SBN: Sbal195_2975
SBP: Sbal223_1528
SLO: Shew_2572
SPC: Sputcn32_1717
SSE: Ssed_1456
SPL: Spea_2799
SHE: Shewmr4_2324
SHM: Shewmr7_2396
SHN: Shewana3_1670
SHW: Sputw3181_2308
SHL: Shal_2904
SWD: Swoo_3225
SWP: swp_3444
SVO: SVI_1281
ILO: IL0876
CPS: CPS_1601
PHA: PSHAa1450
PAT: Patl_2927
MAQ: Maqu_2124
AMC: MADE_02414
CBU: CBU_0976
CBS: COXBURSA331_A0963
CBD: CBUD_1071
CBG: CbuG_1029
CBC: CbuK_0863
LPN: lpg1828
LPF: lpl1792
LPP: lpp1791
LPC: LPC_1272
LPA: lpa_02641
LLO: LLO_1075
NOC: Noc_1889
NHL: Nhal_2500
HCH: HCH_03945
ABO: ABO_1238
AHA: AHA_2076
ASA: ASA_1910
KKO: Kkor_1057
CVI: CV_1763
LHK: LHK_00789
RSO: RSc0267
RPI: Rpic_0118
RPF: Rpic12D_0126
REU: Reut_A1464
REH: H16_A0179
RME: Rmet_0113
CTI: RALTA_A0122
BMA: BMAA0804
BMV: BMASAVP1_0540
BML: BMA10229_0652
BMN: BMA10247_A1606
BPS: BPSS1446
BPM: BURPS1710b_A0469
BPL: BURPS1106A_A1957
BPD: BURPS668_A2054
BTE: BTH_II0949
BVI: Bcep1808_5067
BUR: Bcep18194_B1319
BCN: Bcen_3840
BCH: Bcen2424_4528
BCM: Bcenmc03_5034 Bcenmc03_5776
BCJ: BCAM1710 BCAM2431
BAM: Bamb_3958
BAC: BamMC406_4421 BamMC406_5119
BMU: Bmul_3468 Bmul_4127
BMJ: BMULJ_04378(paaG) BMULJ_05048(paaG)
BXE: Bxe_B0962
BPH: Bphy_3560
BPY: Bphyt_4688
BGL: bglu_2g11280
BGE: BC1002_4301
BPE: BP1702
BPA: BPP3072
BBR: BB3035
BPT: Bpet2564
RFR: Rfer_3831
POL: Bpro_4159
PNA: Pnap_0473
AAV: Aave_4353
AJS: Ajs_3761
DIA: Dtpsy_3042
VEI: Veis_1346
DAC: Daci_5972
VAP: Vapar_4721
CTT: CtCNB1_0505
MPT: Mpe_A3358
HSE: Hsero_3076(caiD)
LCH: Lcho_2117
TIN: Tint_2722 Tint_3010
EBA: ebA3642
AZO: azo3069(paaG5)
DAR: Daro_0090
TMZ: Tmz1t_0750 Tmz1t_1507
APP: CAP2UW1_4327
GME: Gmet_3291
SME: SM_b21126(eccH2)
SMD: Smed_4537
ARA: Arad_1378(fadB1)
AVI: Avi_7690
RHI: NGR_b11650
BMF: BAB1_0016
BMC: BAbS19_I00130
BMT: BSUIS_A0017
BCS: BCAN_A0016
BMR: BMI_I16
OAN: Oant_0041
BJA: bll0116
XAU: Xaut_1856
AZC: AZC_4592
MNO: Mnod_8253
CCR: CC_2169
CCS: CCNA_02251
CAK: Caul_3153
CSE: Cseg_2819
PZU: PHZ_c1289
SIL: SPO2787
SIT: TM1040_0740
RSP: RSP_2511
RSH: Rsph17029_1173
RSQ: Rsph17025_2008
RSK: RSKD131_0826
RCP: RCAP_rcc01516(menB)
JAN: Jann_1150
RDE: RD1_3294
DSH: Dshi_1304(mvaA)
MMR: Mmar10_1729
HNE: HNE_1282
HBA: Hbal_2015
ACR: Acry_1515
RRU: Rru_A1942
RCE: RC1_0385
MAG: amb0675
AZL: AZL_a02270(paaG)
SVI: Svir_12770
ABA: Acid345_1426
SRM: SRM_01669(fadB)
RMR: Rmar_1266
CPI: Cpin_1666
PHE: Phep_2546
RBI: RB2501_07455
PSL: Psta_0090
RCA: Rcas_0977
CAU: Caur_1565
CAG: Cagg_1800
CHL: Chy400_1700
STI: Sthe_2512
TRA: Trad_1575
Taxonomy
Reference
  Authors
  Title

  Journal
 1  [PMID:13535602]
HILZ H, KNAPPE J, RINGELMANN E, LYNEN F.
[Methylglutaconase, a new hydrase participating in the metabolism of
various carboxylic acids.]
Biochem. Z. 329 (1958) 476-89.
Other DBs ExplorEnz - The Enzyme Database: 4.2.1.18
IUBMB Enzyme Nomenclature: 4.2.1.18
ExPASy - ENZYME nomenclature database: 4.2.1.18
BRENDA, the Enzyme Database: 4.2.1.18
CAS: 9024-24-2
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