KEGG   ENZYME: 4.2.1.39Help
Entry
EC 4.2.1.39                 Enzyme                                 

Name
gluconate dehydratase;
D-gluconate dehydratase;
D-gluconate hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
Reaction(IUBMB)
D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O [RN:R01538]
Reaction(KEGG)
Substrate
D-gluconate [CPD:C00257]
Product
2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
H2O [CPD:C00001]
Comment
The enzyme shows no activity with D-galactonate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase.
History
EC 4.2.1.39 created 1972
Pathway
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Reference
1  [PMID:5383859]
  Authors
Andreesen JR, Gottschalk G.
  Title
The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum.
  Journal
Arch. Mikrobiol. 69 (1969) 160-70.
Reference
2  [PMID:4772682]
  Authors
Bender R, Gottschalk G
  Title
Purification and properties of D-gluconate dehydratase from Clostridium pasteurianum.
  Journal
Eur. J. Biochem. 40 (1973) 309-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37290-75-8

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