KEGG   ENZYME: 4.2.1.44Help
Entry
EC 4.2.1.44                 Enzyme                                 

Name
myo-inosose-2 dehydratase;
inosose 2,3-dehydratase;
ketoinositol dehydratase;
2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)
Reaction(IUBMB)
2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O [RN:R02782]
Reaction(KEGG)
Substrate
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691]
Product
3,5/4-trihydroxycyclohexa-1,2-dione [CPD:C04287];
H2O [CPD:C00001]
Comment
Requires Co2+ or Mn2+.
History
EC 4.2.1.44 created 1972
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K03335  inosose dehydratase
Genes
ECQ: ECED1_0303(iolE)
STM: STM4424
SEO: STM14_5316
SEV: STMMW_43681
SEY: SL1344_4356(iolE)
SEM: STMDT12_C45530
SEJ: STMUK_4410
SEB: STM474_4621(iolE)
SEF: UMN798_4791(iolE)
SETU: STU288_22190
SEND: DT104_44121(iolE)
SENI: CY43_23055
SENS: Q786_21800
SENE: IA1_21570
ENC: ECL_03801(iolE)
EEC: EcWSU1_03309(mocC)
CSK: ES15_3054(iolE)
CTU: CTU_09000(iolE)
KPE: KPK_2564 KPK_4085(mocC) KPK_4988(iolE)
KPR: KPR_0654(iolE) KPR_4057
KPX: PMK1_02145(iolE_1) PMK1_02830(iolE_2) PMK1_04134(iolE_4)
EAE: EAE_09830
EAR: CCG32070
CKO: CKO_03985
CWE: CO701_04380(iolE)
LNI: CWR52_18660(iolE)
YPE: YPO2586
YPK: y1154
YPA: YPA_2514
YPN: YPN_1070
YPM: YP_1129(iolE)
YPZ: YPZ3_2285
YPD: YPD4_2430
YPX: YPD8_2263
YPH: YPC_3291
YPW: CH59_3458(iolE)
YPJ: CH55_1591(iolE)
YPV: BZ15_952(iolE)
YPL: CH46_2530(iolE)
YPS: YPTB1079
YPO: BZ17_1464(iolE)
YPY: YPK_3040
YPB: YPTS_1135
YPQ: DJ40_1194
YPU: BZ21_329(iolE)
YPR: BZ20_948(iolE)
YPC: BZ23_607(iolE)
YPF: BZ19_437(iolE)
YEN: YE4025
YEY: Y11_31721
YEL: LC20_00218(iolE)
YEW: CH47_3707
YET: CH48_1476(iolE)
YAL: AT01_2644(iolE)
YFR: AW19_3427
YIN: CH53_1592(iolE)
YKR: CH54_2363(iolE)
YRO: CH64_2438(iolE)
YMA: DA391_00640(iolE)
SRL: SOD_c18650(mocC1) SOD_c29080(mocC) SOD_c44540(iolE)
SPLY: Q5A_010285(iolE_1) Q5A_016160(iolE_3) Q5A_024250(iolE_5)
SMAF: D781_4368
SMAR: SM39_4124(iolE)
SERA: Ser39006_021265(iolE)
ECA: ECA1464(mocC)
PATR: EV46_07415
PATO: GZ59_15030(mocC)
PCT: PC1_1342
PEC: W5S_2979
DDD: Dda3937_01209(mocC)
DDQ: DDI_0584
DFN: CVE23_04305(iolE)
ETA: ETA_32860(iolE) ETA_33740
EPY: EpC_34970(iolE)
EPR: EPYR_03756(iolE)
EAM: EAMY_3504(iolE)
EAY: EAM_3303(iolE)
ERJ: EJP617_09780(iolE)
EGE: EM595_0257(iolE)
PAM: PANA_1626(mocC) PANA_3737(iolE)
PAJ: PAJ_0975(mocC) PAJ_2961(iolE) PAJ_p0235(mocC)
PVA: Pvag_3021(iolE) Pvag_3596(mocC)
PAGG: AL522_18865(iolE) AL522_22250(iolE)
PSTW: DSJ_01305
PLU: plu1800
PAY: PAU_02715
XBV: XBW1_1519(mocC)
XNE: XNC1_2980
XNM: XNC2_2860
XDO: XDD1_1042(mocC)
XPO: XPG1_3264(mocC)
PSI: S70_04140
PSX: DR96_6
PRG: RB151_031020(iolE)
ETE: ETEE_3700(iolE)
PSHI: SAMEA2665130_0891(iolE)
HAP: HAPS_1533(iolE)
HPAZ: K756_10585
HPAS: JL26_09120
HPAK: JT17_07235
HSO: HS_1577(iolE)
HSM: HSM_0434
MHT: D648_2450(iolE)
MHQ: D650_25690(iolE)
MHAT: B824_24170(iolE)
MHX: MHH_c07890(iolE)
MHAE: F382_06895
MHAM: J450_08145
MHAO: J451_09330
MHAL: N220_01190
MHAQ: WC39_12875
MHAY: VK67_12880
MVI: X808_1650
MVG: X874_1730
AAN: D7S_00597
AACN: AANUM_1311(iolE)
BTO: WQG_22460
BTRE: F542_150
BTRH: F543_160
BTRA: F544_22980
VAN: VAA_01480
PPR: PBPRB0461(CTC00512) PBPRB0477(BRA0715)
PSB: Psyr_3273
PSYR: N018_16425
PAMG: BKM19_019170(iolE)
PAVL: BKM03_11740(iolE)
PFL: PFL_2587(iolE)
PPRC: PFLCHA0_c26520(mocC)
PPRO: PPC_2634
PFS: PFLU_2576
PFC: PflA506_3034(iolE)
PFW: PF1751_v1c22340(iolE)
PFB: VO64_5688
PMAN: OU5_0767
PSEM: TO66_12590
PSOS: POS17_2591
PANR: A7J50_2467
PTN: PTRA_b0331(iolE)
LPN: lpg1649(iolE)
LPH: LPV_1905(iolE)
LPO: LPO_1685(iolE)
LPM: LP6_1627(iolE)
LPF: lpl1615(iolE)
LPP: lpp1620(iolE)
LPC: LPC_1079(iolE)
LPA: lpa_02384(iolE)
LPE: lp12_1587
LLO: LLO_2232(iolE)
LFA: LFA_1670(iolE)
LHA: LHA_0081(iolE)
LSH: CAB17_16490(iolE)
MPSY: CEK71_08020(iolE)
TNI: TVNIR_3329(iolE_[H])
GAI: IMCC3135_16510(iolE_1) IMCC3135_21450(iolE_2)
HCH: HCH_01158
HEL: HELO_4231(iolE)
HAM: HALO0576
HBE: BEI_3709(iolE)
RSO: RSc1238(iolE) RSc1247
RSC: RCFBP_20183(iolE)
RSL: RPSI07_2119(iolE)
RSN: RSPO_c02117(iolE)
BMA: BMA0911
BMAL: DM55_2128
BMAE: DM78_2154
BMAQ: DM76_2103
BMAI: DM57_2967
BMAF: DM51_666(iolE)
BMAZ: BM44_2338
BMAB: BM45_1903(iolE)
BPS: BPSL1996
BPM: BURPS1710b_1829(iolE)
BPSE: BDL_531
BPSM: BBQ_1867
BPSU: BBN_1993
BPSD: BBX_2471
BPK: BBK_42
BPSH: DR55_3107
BPSA: BBU_702
BPSO: X996_2721
BUT: X994_1175(iolE)
BTE: BTH_I2649
BTQ: BTQ_1375
BTJ: BTJ_1077
BTZ: BTL_2318
BTD: BTI_2392
BTV: BTHA_2517
BTHE: BTN_2450
BTHM: BTRA_2598
BTHA: DR62_2595
BTHL: BG87_2542(iolE)
BOK: DM82_946
BOC: BG90_3656(iolE)
BVE: AK36_2558(iolE)
BMUL: NP80_1502(iolE) NP80_1510
BDL: AK34_1743 AK34_1751(iolE)
BUB: BW23_321(iolE)
BMEC: WJ16_06865
BGU: KS03_3040(iolE)
BGO: BM43_2961
BUK: MYA_1256
BUL: BW21_2359(iolE)
BXE: Bxe_A1324
BXB: DR64_3485
BPH: Bphy_1602
BFN: OI25_2611(iolE)
PARB: CJU94_10900(iolE)
PHS: C2L64_05105(iolE)
PTER: C2L65_04900(iolE)
ASW: CVS48_05210(iolE)
DAC: Daci_2932
JAG: GJA_2983
JSV: CNX70_12870(iolE)
HSE: Hsero_2429(iolE)
CFU: CFU_1942(iolE)
CARE: LT85_2684
LCH: Lcho_3316
SME: SMc00433(iolE)
SMX: SM11_chr3829(iolE)
SMI: BN406_03483(mocC)
SMEL: SM2011_c00433(iolE)
SMER: DU99_01890
SFD: USDA257_c16280(iolE1) USDA257_c62080(iolE2)
SIX: BSY16_1810(iolE) BSY16_6003(iolE) BSY16_6023
ATU: Atu4510(iolE) Atu5434
ARA: Arad_0106(iolE) Arad_1557(iolE) Arad_3958
ATF: Ach5_42090(iolE)
AVI: Avi_0078(iolE) Avi_7455
AGC: BSY240_3770(iolE)
REI: IE4771_CH01430(iolE-1) IE4771_PD00506(iolE-2)
REP: IE4803_CH01383(iolE-1) IE4803_PC00496(iolE-2)
RLE: RL1416 RL1493(mocC)
RTR: RTCIAT899_CH05705(iolE)
RGA: RGR602_CH01266(iolE-1) RGR602_PC00352(iolE-2) RGR602_PC00467(iolE-3) RGR602_PC00473(iolE-4)
RHN: AMJ98_CH01382(iolE-1) AMJ98_PE00524(iolE-2)
RPHA: AMC79_CH01396(iolE-1) AMC79_PD00662(iolE-2)
RHT: NT26_3245(mocC)
RHX: AMK02_CH01387(iolE)
BME: BMEII0570
BMEL: DK63_2677
BMZ: BM28_B0685(iolE)
BMG: BM590_B0683(iolE)
BMEE: DK62_2725
BMF: BAB2_0524
BMB: BruAb2_0515(iolE)
BABO: DK55_2503
BABR: DO74_2918
BABT: DK49_2736
BABB: DK48_2188
BABU: DK53_2506
BABS: DK51_3090
BABC: DO78_2552
BMS: BRA0715(iolE)
BSI: BS1330_II0708(iolE)
BSF: BSS2_II0679(iolE)
BSZ: DK67_2681
BSV: BSVBI22_B0707(iolE)
BOV: BOV_A0671(iolE)
BCS: BCAN_B0721(mocC)
BOL: BCOUA_II0715(iolE)
BCAR: DK60_2416
BCAS: DA85_13895
BMR: BMI_II709(iolE)
BPP: BPI_II769(iolE)
BPV: DK65_2921
BVL: BF3285c2_0247(iolE)
OAN: Oant_3839
OAH: DR92_2652
BRA: BRADO2242
BBT: BBta_0486
BRAD: BF49_1333
BOS: BSY19_4201(iolE)
MPO: Mpop_4213
MNO: Mnod_7800
META: Y590_08000
BID: Bind_2835
DEQ: XM25_16755(MocC)
MMED: Mame_02152(iolE_2)
HDI: HDIA_4577(iolE_3)
CCR: CC_1300
CCS: CCNA_01358(iolE)
RSP: RSP_3285(iolE)
JAN: Jann_1422
RDE: RD1_0223
PDE: Pden_1674
PYE: A6J80_02340(iolE)
PARO: CUV01_06160(iolE) CUV01_06220(iolE)
DSH: Dshi_1271
KVU: EIO_3044
PGD: Gal_02765
OTM: OSB_26420(iolE_2)
SAGU: CDO87_05560(iolE)
HNE: HNE_2184(iolE)
SMAZ: LH19_12510
SPHO: C3E99_18765(iolE)
SPHI: TS85_08280
GOX: GOX1183
GOY: GLS_c12740(iolE)
ACR: Acry_2325
GDI: GDI0363(iolE)
GDJ: Gdia_2414
GXY: GLX_02000
ABG: Asbog_00337(iolE) Asbog_00356(iolE)
AZL: AZL_b01040(iolE)
TXI: TH3_14085
THAC: CSC3H3_21665(iolE)
NAO: Y958_30100(iolE)
NCB: C0V82_17550(iolE)
BSU: BSU39720(iolE)
BSL: A7A1_1970
BSH: BSU6051_39720(iolE)
BSUT: BSUB_04214(iolE)
BSUL: BSUA_04214(iolE)
BSUS: Q433_21925
BSS: BSUW23_19820(iolE)
BST: GYO_4379
BSO: BSNT_10659(iolE)
BSQ: B657_39720(iolE)
BSX: C663_3891(iolE)
BLI: BL00242(iolE)
BLD: BLi04247(iolE)
BLH: BaLi_c42380(iolE)
BAY: RBAM_036740(iolE)
BAQ: BACAU_3688(iolE)
BYA: BANAU_3858(iolE)
BAMP: B938_18840
BAML: BAM5036_3594(iolE)
BAMA: RBAU_3801(iolE)
BAMN: BASU_3583(iolE)
BAMB: BAPNAU_3865(iolE)
BAMT: AJ82_20725
BAMY: V529_39410(iolE)
BMP: NG74_03848(iolE_2)
BAO: BAMF_3784(iolE)
BAZ: BAMTA208_20010(iolE)
BQL: LL3_04107(iolE)
BXH: BAXH7_04105(iolE)
BQY: MUS_4363(iolE)
BAMI: KSO_000720
BAMC: U471_38330
BAMF: U722_19570
BATR: TD68_16760
BHA: BH2317(iolE)
BANV: DJ46_1295
BCZ: BCE33L2255(iolE) pE33L466_0303(iolE)
BCX: BCA_2600
BAL: BACI_c24840(iolE)
BCF: bcf_12595
BCER: BCK_22280
BTK: BT9727_2299(iolE)
BTL: BALH_2261
BTM: MC28_G012(iolE2)
BTW: BF38_3701
BWW: bwei_1732(iolE)
BCL: ABC0426(iolE)
BMEG: BG04_2786(iolE) BG04_546
BJS: MY9_4103
BACP: SB24_10390
BACB: OY17_02045
BACL: BS34A_42980(iolE)
BGY: BGLY_1322 BGLY_4633(iolE)
BKW: BkAM31D_16265(iolE)
GKA: GK1890(iolE)
GTN: GTNG_1809(iolE)
ANM: GFC28_277(iolE)
ANL: GFC29_1347(iolE)
VPN: A21D_00415(iolE)
SAGQ: EP23_08675
SSCU: CEP64_10835(iolE)
SKL: C7J89_01175(iolE)
BTHS: CNY62_11305(iolE)
PPY: PPE_00858
PMS: KNP414_06106(iolE)
PMW: B2K_29195
PLV: ERIC2_c08140(iolE2)
PDH: B9T62_31125(iolE)
JEO: JMA_08630
LPL: lp_3607(iolE)
LCB: LCABL_02230(iolE)
LCS: LCBD_0223
LCE: LC2W_0214
LCW: BN194_02290(iolE)
LRH: LGG_00268(iolE)
LRG: LRHM_0264
LRL: LC705_00259(iolE)
LRA: LRHK_270(iolE)
EFI: OG1RF_11782(iolE)
EFN: DENG_02295(iolE)
CML: BN424_2309(iolE)
CPE: CPE0091
CPF: CPF_0086(iolE)
CTC: CTC_00512(iolE)
CTET: BN906_00538(iolE)
CBK: CLL_A1306
CBN: CbC4_1947
CBT: CLH_1257
CBE: Cbei_4546
CBZ: Cbs_4546
CBEI: LF65_05074
CPAT: CLPA_c10960(iolE)
CPAE: CPAST_c10960(iolE)
CSB: CLSA_c12160(iolE)
CTYK: CTK_C07510
CTAE: BGI42_06010(iolE)
CCEL: CCDG5_1866
CTHD: CDO33_05890(iolE)
RUM: CK1_01420
BHU: bhn_I0096
THX: Thet_1929
PUF: UFO1_3165
PFT: JBW_01418
MHY: mhp148
MHJ: MHJ_0224(iolE)
MHP: MHP7448_0230(iolE)
MHN: MHP168_249(iolE)
MHYO: MHL_2983(iolE)
MGI: Mflv_2612
MVQ: MYVA_0358(iolE) MYVA_3811
CGL: NCgl0160(Cgl0163)
CGB: cg0203(iolE)
CGU: WA5_0160(IolE)
CGT: cgR_0242
CGM: cgp_0203(iolE)
CGJ: AR0_01105
CAMG: CAMM_03520
RER: RER_20170(iolE) RER_20380
RHU: A3Q40_02121(iolE_1) A3Q40_02132(iolE_2)
TPR: Tpau_1362
SCO: SCO6982(SC8F11.08)
SMA: SAVERM_5337(iolE1) SAVERM_7154(iolE2)
SGR: SGR_4833
SGB: WQO_11355
SCT: SCAT_4796
SFA: Sfla_4183
SHY: SHJG_7721
SVE: SVEN_2527
SALB: XNR_4236
SALS: SLNWT_5031
STRP: F750_2534
SFI: SFUL_2280
SALU: DC74_3215
SALL: SAZ_17150
STRE: GZL_05698
SLD: T261_5347
STRM: M444_13180
SPRI: SPRI_4816
SRW: TUE45_07379(iolE)
SLE: sle_08690(sle_08690)
SRN: A4G23_00279(iolE)
STRD: NI25_04270
SMAL: SMALA_2750
SLAU: SLA_2490
SALF: SMD44_03031(iolE)
SALJ: SMD11_4427(iolE)
SLX: SLAV_24080(iolE)
LXX: Lxx24330
CMI: CMM_0794
CMC: CMN_00750
MTS: MTES_1736
ARR: ARUE_c21340(iolE)
ARX: ARZXY2_2957(iolE)
AAU: AAur_1981
ACH: Achl_0941
RSA: RSal33209_0363(iolE.1)
BCV: Bcav_0730
LMOI: VV02_10205
PAC: PPA0468
PAW: PAZ_c04880(iolE)
PACC: PAC1_02405
PACH: PAGK_0485
CACN: RN83_02840
PFR: PFREUD_19010(iolE)
MPH: MLP_05730 MLP_23520(iolE) MLP_39370(iolE)
ACE: Acel_1816
NML: Namu_3352
GOB: Gobs_2746
MMAR: MODMU_2735
KRA: Krad_4055
SEN: SACE_3277 SACE_4659(iolE) SACE_5192(iolE)
AMD: AMED_1888(iolE) AMED_7251(iolE)
AMM: AMES_1874(iolE) AMES_7141(iolE)
AMZ: B737_1875(iolE) B737_7141(iolE)
AOI: AORI_5990(iolE)
PSEA: WY02_00735
AMI: Amir_6852
KAL: KALB_8537
SAQ: Sare_2490
AMS: AMIS_48590(iolE)
ASE: ACPL_2918(iolE)
ACTS: ACWT_2628
SNA: Snas_0657
AHE: Arch_0041
TPYO: X956_00785
TBI: Tbis_3079
RXY: Rxyl_1722
ANA: alr1580
AVA: Ava_4190
TRA: Trad_1229
MRB: Mrub_1696
CAA: Caka_0958
PSL: Psta_4596
IPA: Isop_2135
PHE: Phep_1346
LBY: Lbys_0018
KOL: Kole_0988
HMU: Hmuk_0320
CMA: Cmaq_1498
 » show all
Taxonomy
Reference
1  [PMID:5905122]
  Authors
Berman T, Magasanik B.
  Title
The pathway of myo-inositol degradation in Aerobacter aerogenes. Dehydrogenation and dehydration.
  Journal
J. Biol. Chem. 241 (1966) 800-6.
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.44
IUBMB Enzyme Nomenclature: 4.2.1.44
ExPASy - ENZYME nomenclature database: 4.2.1.44
BRENDA, the Enzyme Database: 4.2.1.44
CAS: 37290-79-2

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