KEGG   ENZYME: 4.2.1.57Help
Entry
EC 4.2.1.57                 Enzyme                                 

Name
isohexenylglutaconyl-CoA hydratase;
3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase;
isohexenylglutaconyl coenzyme A hydratase;
beta-isohexenylglutaconyl-CoA-hydratase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
Reaction(IUBMB)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O [RN:R03493]
Reaction(KEGG)
Substrate
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]
Product
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291];
H2O [CPD:C00001]
Comment
Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
History
EC 4.2.1.57 created 1972
Pathway
ec00281  Geraniol degradation
Orthology
K13779  isohexenylglutaconyl-CoA hydratase
Genes
PAE: PA2890(atuE)
PAEV: N297_2993
PAEI: N296_2993
PAU: PA14_26690
PAP: PSPA7_2264
PAG: PLES_21741(atuE)
PAF: PAM18_2073(atuE)
PNC: NCGM2_4001
PAEB: NCGM1900_3421
PDK: PADK2_09920
PAEP: PA1S_10960
PAEM: U769_10500
PAEL: T223_10970
PAEU: BN889_03228(atuE)
PAEG: AI22_22910
PAEC: M802_2990
PAEO: M801_2858
PMY: Pmen_2693
PMK: MDS_2025
PPSE: BN5_2437
PCQ: PcP3B5_19980(echA8_1)
PFL: PFL_4198(atuE)
PPRC: PFLCHA0_c42610(echA5)
PPRO: PPC_4295(atuE)
PFS: PFLU_4396
PFC: PflA506_3700(atuE)
PFW: PF1751_v1c38910(atuE)
PFB: VO64_5140
PMAN: OU5_1499
PKC: PKB_3705
PSOS: POS17_4286(atuE)
PANR: A7J50_4074
PSET: THL1_3722
PSIL: PMA3_07215
ACB: A1S_3006
ABM: ABSDF2869
ABY: ABAYE0482
ABN: AB57_3457
ABX: ABK1_3257
ABH: M3Q_3438
ABAD: ABD1_28950
ABAZ: P795_2375
ABAU: IX87_11725
ABAA: IX88_17970
ACC: BDGL_002470(ech2)
PAT: Patl_0318
MAQ: Maqu_2806
MHC: MARHY2693
MAD: HP15_2541
SAGA: M5M_01895
MICC: AUP74_02724(caiD_2)
CYQ: Q91_1220
HCH: HCH_05751
ABO: ABO_0987(ech2)
ADI: B5T_01798(ech2)
APAC: S7S_10300
AXE: P40_08545
OAI: OLEAN_C05750(ech)
REH: H16_A2138(h16_A2138)
RME: Rmet_1723
BPS: BPSS2033
BPSE: BDL_5456
BPSM: BBQ_4088
BPSU: BBN_5508
BPSD: BBX_4623
BPK: BBK_4784
BPSH: DR55_5688
BPSA: BBU_3965
BPSO: X996_5493
BUT: X994_5050
BTQ: BTQ_3582
BTJ: BTJ_4618
BTZ: BTL_5405
BTD: BTI_4953
BTV: BTHA_4797
BTHE: BTN_5076
BTHM: BTRA_5344
BTHA: DR62_5205
BTHL: BG87_5412
BOK: DM82_6352
BOC: BG90_4322
BUL: BW21_4481
RFR: Rfer_2816
ACRA: BSY15_2085
CTES: O987_10850
LIH: L63ED372_00597(paaF_2)
HYB: Q5W_16945
RGE: RGE_32890
RVA: Rvan_3071
PZU: PHZ_p0199
PSF: PSE_4602
SFLA: SPHFLASMR4Y_02318(caiD)
RCE: RC1_3532
TMO: TMO_b0367
 » show all
Taxonomy
Reference
1  [PMID:14339651]
  Authors
SEUBERT W, FASS E.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]
  Journal
Biochem. Z. 341 (1964) 23-34.
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.57
IUBMB Enzyme Nomenclature: 4.2.1.57
ExPASy - ENZYME nomenclature database: 4.2.1.57
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.57
BRENDA, the Enzyme Database: 4.2.1.57
CAS: 37290-84-9

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