KEGG   ENZYME: 4.2.1.74Help
Entry
EC 4.2.1.74                 Enzyme                                 

Name
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O [RN:R02685]
Reaction(KEGG)
Substrate
long-chain (3S)-3-hydroxyacyl-CoA
Product
long-chain trans-2-enoyl-CoA;
H2O [CPD:C00001]
Comment
Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
History
EC 4.2.1.74 created 1981
Pathway
Fatty acid elongation
Fatty acid degradation
Metabolic pathways
Reference
1  [PMID:833142]
  Authors
Fong JC, Schulz H.
  Title
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues.
  Journal
J. Biol. Chem. 252 (1977) 542-7.
  Organism
Sus scofa, Cavia porcellus
Reference
2  [PMID:4828315]
  Authors
Schulz H.
  Title
Long chain enoyl coenzyme A hydratase from pig heart.
  Journal
J. Biol. Chem. 249 (1974) 2704-9.
  Organism
Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62009-81-8

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