KEGG   ENZYME: 4.2.1.77Help
Entry
EC 4.2.1.77                 Enzyme                                 

Name
trans-L-3-hydroxyproline dehydratase;
trans-L-3-hydroxyproline hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
trans-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O [RN:R04374]
Reaction(KEGG)
Substrate
trans-3-hydroxy-L-proline [CPD:C05147]
Product
1-pyrroline 2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
Comment
Highly specific.
History
EC 4.2.1.77 created 1984
Pathway
Arginine and proline metabolism
Orthology
K18384  
trans-L-3-hydroxyproline dehydratase
Genes
HSA: 
112849(L3HYPDH)
PPS: 
100973980(L3HYPDH)
GGO: 
101151045(L3HYPDH)
PON: 
100172276(L3HYPDH)
NLE: 
100585615(L3HYPDH)
MCC: 
702076(L3HYPDH)
MCF: 
102115940(L3HYPDH)
CSAB: 
103229098(L3HYPDH)
RRO: 
104662157(L3HYPDH)
RBB: 
108524789(L3HYPDH)
CJC: 
100402030(L3HYPDH)
SBQ: 
101037339(L3HYPDH)
MMU: 
67217(L3hypdh)
RNO: 
314214(L3hypdh)
CGE: 
100764709(L3hypdh)
NGI: 
103739192(L3hypdh)
HGL: 
101725460(L3hypdh)
CCAN: 
109696080(L3hypdh)
OCU: 
100354746(L3HYPDH)
TUP: 
102490555(L3HYPDH)
CFA: 
490715(L3HYPDH)
AML: 
100471249(L3HYPDH)
UMR: 
103672703(L3HYPDH)
FCA: 
101098960(L3HYPDH)
PTG: 
102955955(L3HYPDH)
AJU: 
106974568(L3HYPDH)
BTA: 
510525(L3HYPDH)
BOM: 
102267712(L3HYPDH)
BIU: 
109565207(L3HYPDH)
PHD: 
102331969(L3HYPDH)
CHX: 
102170980(L3HYPDH)
OAS: 
101102239(L3HYPDH)
SSC: 
110262303(L3HYPDH)
CFR: 
102510698(L3HYPDH)
CDK: 
105086230(L3HYPDH)
BACU: 
103001798(L3HYPDH)
LVE: 
103089729(L3HYPDH)
ECB: 
100059502(L3HYPDH)
EPZ: 
103560585(L3HYPDH)
EAI: 
106846079(L3HYPDH)
MYB: 
102251331(L3HYPDH)
MYD: 
102751344(L3HYPDH)
HAI: 
109383857(L3HYPDH)
RSS: 
109444418(L3HYPDH)
PALE: 
102892379(L3HYPDH)
LAV: 
100671364(L3HYPDH)
MDO: 
100026616(L3HYPDH)
SHR: 
100916958(L3HYPDH)
OAA: 
100086994(L3HYPDH)
GGA: 
423531(L3HYPDH)
MGP: 
104911286(L3HYPDH)
CJO: 
107315418(L3HYPDH)
APLA: 
101790625(L3HYPDH)
ACYG: 
106037183(L3HYPDH)
TGU: 
100232596(L3HYPDH)
GFR: 
102042007(L3HYPDH)
FAB: 
101810740(L3HYPDH)
PHI: 
102107944(L3HYPDH)
PMAJ: 
107206387(L3HYPDH)
CCW: 
104684550(L3HYPDH)
FPG: 
101918943(L3HYPDH)
FCH: 
102059456(L3HYPDH)
CLV: 
102096316(L3HYPDH)
AAM: 
106495231(L3HYPDH)
ASN: 
102369998(L3HYPDH)
AMJ: 
102565530(L3HYPDH)
PSS: 
102462476(L3HYPDH)
CMY: 
102947990(L3HYPDH)
CPIC: 
101931630(L3HYPDH)
ACS: 
100559609(l3hypdh)
PVT: 
110083781(L3HYPDH)
PBI: 
103049310(L3HYPDH)
GJA: 
107120397(L3HYPDH)
XLA: 
XTR: 
493490(l3hypdh)
NPR: 
108791712(L3HYPDH)
DRE: 
565785(l3hypdh)
SRX: 
SANH: 
SGH: 
107601901(l3hypdh)
IPU: 
108257951(l3hypdh)
AMEX: 
103042342(l3hypdh)
TRU: 
101066682(l3hypdh)
TNG: 
LCO: 
104930547(l3hypdh)
NCC: 
104951072(l3hypdh)
MZE: 
101483912(l3hypdh)
OLA: 
101166521(l3hypdh)
XMA: 
102217165(l3hypdh)
LCF: 
108895649(l3hypdh)
HCQ: 
109524865(l3hypdh)
BPEC: 
110155871(l3hypdh)
SASA: 
106571502(l3hypdh)
ELS: 
105017645(l3hypdh)
SFM: 
108930829(l3hypdh)
LCM: 
102352794(L3HYPDH)
CMK: 
103178517(l3hypdh)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
NVE: 
EPA: 
ADF: 
HMG: 
AQU: 
MTM: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
MAW: 
MAJ: 
PLJ: 
CFJ: 
PFY: 
PSCO: 
ANI: 
AFM: 
AOR: 
ANG: 
ANI_1_1948074(An08g04750)
AFV: 
NFI: 
PDP: 
PNO: 
PFJ: 
NPA: 
TVS: 
DSQ: 
PSQ: 
MRR: 
MESW: 
 » show all
Taxonomy
Reference
1
  Authors
Ramaswamy, S.G.
  Title
Conversion of 3-hydroxyproline to proline in the rat requires reduced pyridine-nucleotides.
  Journal
Fed. Proc. 42 (1983) 2232.
Reference
2  [PMID:22528483]
  Authors
Visser WF, Verhoeven-Duif NM, de Koning TJ
  Title
Identification of a human trans-3-hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes.
  Journal
J. Biol. Chem. 287 (2012) 21654-62.
  Sequence
[hsa:112849]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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