KEGG   ENZYME: 4.2.1.80Help
Entry
EC 4.2.1.80                 Enzyme                                 
Name 2-oxopent-4-enoate hydratase;
2-keto-4-pentenoate hydratase;
OEH;
2-keto-4-pentenoate (vinylpyruvate)hydratase;
4-hydroxy-2-oxopentanoate hydro-lyase
Class Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
Reaction(IUBMB) 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O [RN:R02601]
Reaction(KEGG) R02601;
(other) R04781 R05297 R05864
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Substrate 4-hydroxy-2-oxopentanoate [CPD:C03589]
Product 2-oxopent-4-enoate [CPD:C00596];
H2O [CPD:C00001]
Comment Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the
trans-isomer.
Pathway PATH: ec00360  Phenylalanine metabolism
PATH: ec00362  Benzoate degradation via hydroxylation
PATH: ec00621  Biphenyl degradation
PATH: ec00622  Toluene and xylene degradation
PATH: ec00627  1,4-Dichlorobenzene degradation
PATH: ec00628  Fluorene degradation
PATH: ec00629  Carbazole degradation
PATH: ec00642  Ethylbenzene degradation
PATH: ec00643  Styrene degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K02554  2-keto-4-pentenoate hydratase
Genes ECO: b0350(mhpD)
ECJ: JW0341(mhpD)
ECE: Z0448(mhpD)
ECS: ECs0405(mhpD)
ECF: ECH74115_0425(mhpD)
ETW: ECSP_0414(mhpD)
ECW: EcE24377A_0374(mhpD)
ECX: EcHS_A0414(mhpD)
ECM: EcSMS35_0381(mhpD)
ECY: ECSE_0375(mhpD)
ECL: EcolC_3275(mhpD)
ECK: EC55989_0357(mhpD)
ECQ: ECED1_0378(mhpD)
ECR: ECIAI1_0351(mhpD)
ECT: ECIAI39_0328(mhpD)
EUM: ECUMN_0393(mhpD)
EBL: B21_00308(mhpD)
EBD: ECBD_3307
EBR: ECB_00304(mhpD)
SSN: SSON_0329(mhpD)
PLU: plu2201
PAY: PAU_02360(mhpD)
KPN: KPN_02119(mhpD)
KPE: KPK_2204(mhpD)
KPU: KP1_3214(mhpD)
XCC: XCC0145(mhpD)
XCB: XC_0154
XCA: xccb100_0162(mhpD)
XCV: XCV0146
XAC: XAC0161(mhpD)
PPF: Pput_2890
PPW: PputW619_1982(mhpD) PputW619_2011
RSO: RS01662(RSp0891)
REH: H16_B0548(mhpD1) H16_B0597(bphH) H16_B0884(mhpD3)
BUR: Bcep18194_B1186
BCJ: BCAM2124(mhpD)
BXE: Bxe_A1149(amnF) Bxe_A3548 Bxe_C1189(bphH)
BAV: BAV0598(mhpD)
MPT: Mpe_A2273 Mpe_A3325
AZO: azo1853(lapE) azo1974(mhpD) azo2434(nahL)
DAR: Daro_0905 Daro_1354 Daro_2774
CCR: CC_1509
CAK: Caul_1767
MMR: Mmar10_0237
SWI: Swit_0742
GDI: GDI_2732(mhpD)
BCA: BCE_2155
BTL: BALH_1842(pheD)
GTN: GTNG_3153(nbaH)
MTU: Rv3536c
MTC: MT3640(mhpD)
MBO: Mb3566c
MBB: BCG_3600c
MPA: MAP0531
MAV: MAV_0625
NFA: nfa30420 nfa33180 nfa4650
RHA: RHA1_ro00517 RHA1_ro03881 RHA1_ro08085(bphE3)
     RHA1_ro10117(bphE4)
SCO: SCP1.55c
TTJ: TTHB239
Taxonomy
Structures PDB: 2WQT  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:7287632]
Kunz DA, Ribbons DW, Chapman PJ.
Metabolism of allylglycine and cis-crotylglycine by Pseudomonas
putida (arvilla) mt-2 harboring a TOL plasmid.
J. Bacteriol. 148 (1981) 72-82.
Pseudomonas putida
Other DBs ExplorEnz - The Enzyme Database: 4.2.1.80
IUBMB Enzyme Nomenclature: 4.2.1.80
ExPASy - ENZYME nomenclature database: 4.2.1.80
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.80
BRENDA, the Enzyme Database: 4.2.1.80
CAS: 64427-80-1
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