KEGG   ENZYME: 4.2.1.80Help
Entry
EC 4.2.1.80                 Enzyme                                 
Name
2-oxopent-4-enoate hydratase;
2-keto-4-pentenoate hydratase;
OEH;
2-keto-4-pentenoate (vinylpyruvate)hydratase;
4-hydroxy-2-oxopentanoate hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O [RN:R02601]
Reaction(KEGG)
Substrate
4-hydroxy-2-oxopentanoate [CPD:C03589]
Product
2-oxopent-4-enoate [CPD:C00596];
H2O [CPD:C00001]
Comment
Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer.
Pathway
Phenylalanine metabolism
Benzoate degradation
Dioxin degradation
Xylene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K02554  
2-keto-4-pentenoate hydratase
Genes
ECO: 
b0350(mhpD)
ECJ: 
Y75_p0339(mhpD)
EBW: 
BWG_0239(mhpD)
ECOK: 
ECE: 
Z0448(mhpD)
ECS: 
ECs0405(mhpD)
ECF: 
ETW: 
ECSP_0414(mhpD)
ELX: 
EOJ: 
EOI: 
ECO111_0386(mhpD)
EOH: 
ECO103_0332(mhpD)
EOK: 
G2583_0463(mhpD)
ELR: 
ECO55CA74_02225(mhpD)
ECX: 
EcHS_A0414(mhpD)
ECW: 
EcE24377A_0374(mhpD)
ECM: 
EcSMS35_0381(mhpD)
ECY: 
ECSE_0375(mhpD)
ECR: 
ECIAI1_0351(mhpD)
ECQ: 
ECED1_0378(mhpD)
ECK: 
EC55989_0357(mhpD)
ECT: 
ECIAI39_0328(mhpD)
EOC: 
CE10_0318(mhpD)
EUM: 
ECUMN_0393(mhpD)
ELO: 
EC042_0387(mhpD)
ELH: 
ETEC_0406
ESE: 
ECSF_0321
ESO: 
O3O_05570(mhpD)
ESM: 
O3M_19710(mhpD)
ESL: 
O3K_19725(mhpD)
ECL: 
EcolC_3275(mhpD)
EBR: 
ECB_00304(mhpD)
EBD: 
ECBD_3307(mhpD)
EKO: 
EKO11_3492
EKF: 
KO11_21830(mhpD)
EDH: 
EcDH1_3256
EDJ: 
ECDH1ME8569_0337(mhpD)
ENA: 
ECNA114_0333(mhpD)
EUN: 
UMNK88_400
ELW: 
ECW_m0428(mhpD)
ELL: 
WFL_02105(mhpD)
ELP: 
P12B_c0368(mhpD)
EBL: 
ECD_00304(mhpD)
EBE: 
B21_00308(mhpD)
ECOA: 
APECO78_05270(mhpD)
EBT: 
EBL_c20010(mhpD)
SSN: 
SSON_0329(mhpD)
SSJ: 
SSON53_01790(mhpD)
PLU: 
plu2201
PAY: 
PAU_02360(mhpD)
KPN: 
KPN_02119(mhpD)
KPU: 
KP1_3214(mhpD)
KPM: 
KPHS_31010
KPP: 
A79E_2125
KPE: 
KPK_2204(mhpD)
KPO: 
KPN2242_13550(mhpD)
KVA: 
Kvar_2156
KOX: 
KOX_22680(mhpD)
ROR: 
RORB6_04290(mhpD)
EBF: 
D782_1985
XCC: 
XCC0145(mhpD)
XCB: 
XC_0154
XCA: 
xccb100_0162(mhpD)
XCV: 
XCV0146
XCP: 
XCR_4394
XAC: 
XAC0161(mhpD)
XAX: 
XACM_0146
XAO: 
XAC29_00830
XCI: 
XCAW_00555(mhpD)
PSU: 
Psesu_0023
PSD: 
DSC_09160 DSC_09365
VEJ: 
VEJY3_06795(mhpD)
VFU: 
vfu_A01973
PPF: 
Pput_2890
PPW: 
PputW619_1982(mhpD) PputW619_2011
PPX: 
T1E_4256
PPUH: 
B479_25875(mhpD)
PPUU: 
PputUW4_01660(mhpD)
PFE: 
PSF113_2494
PPZ: 
H045_07780
PSC: 
A458_06520
PBA: 
PSEBR_a2351
PDR: 
H681_08420
AVN: 
Avin_08670(xylJ) Avin_15110(mhpD)
AVL: 
AvCA_08670(xylJ) AvCA_15110(mhpD) AvCA_30610(lapE)
AVD: 
AvCA6_08670(xylJ) AvCA6_15110(mhpD) AvCA6_30610(lapE)
MAD: 
HP15_1113 HP15_4034
AMC: 
MADE_1016425
AMAA: 
amad1_16620
TTU: 
TERTU_1258
CYQ: 
Q91_0508
AEH: 
Mlg_2460
RSO: 
RS01662(RSp0891)
RPI: 
Rpic_4620
RPF: 
Rpic12D_3544
REU: 
Reut_A0272 Reut_B5691
REH: 
H16_B0548(mhpD1) H16_B0597(bphH) H16_B0884(mhpD3)
RME: 
Rmet_1321(xylJ) Rmet_5207(mhpD)
CTI: 
RALTA_B0401(mhpD)
CNC: 
CNE_1c17860(mhpD2) CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)
BVI: 
Bcep1808_5386 Bcep1808_7603
BUR: 
Bcep18194_B1186 Bcep18194_B2961 Bcep18194_C7646
BCJ: 
BCAM1613 BCAM2124(mhpD)
BCT: 
GEM_4111 GEM_5403
BXE: 
Bxe_A1149(amnF) Bxe_A3548 Bxe_B2327 Bxe_C1189(bphH)
BPH: 
Bphy_4537
BPY: 
Bphyt_1466
BUG: 
BC1001_0833
BGE: 
BC1002_4115 BC1002_4722
BRH: 
RBRH_00200
BUK: 
MYA_5004
BPX: 
BUPH_05360
BAV: 
BAV0598(mhpD)
TAS: 
TASI_0989
TAT: 
KUM_0455
PNA: 
Pnap_4144
AJS: 
Ajs_0222
ACK: 
C380_15905(bphE)
VEI: 
Veis_2785
CTT: 
CtCNB1_3149
ADN: 
Alide_0337
ADK: 
Alide2_0282
MPT: 
Mpe_A2273 Mpe_A3325
LCH: 
Lcho_3343
AZO: 
azo1853(lapE) azo1974(mhpD) azo2434(nahL)
DAR: 
Daro_0905 Daro_1354 Daro_2774
TMZ: 
Tmz1t_2077
ARC: 
ABLL_2444
OCG: 
OCA5_c03450
OCO: 
OCA4_c03440
XAU: 
Xaut_0936
CCR: 
CC_1509
CCS: 
CCNA_01577
CAK: 
Caul_1767
CSE: 
Cseg_1571
PZU: 
PHZ_c2453(mhpD)
BSB: 
Bresu_3164
AEX: 
Astex_2117
MMR: 
Mmar10_0237
HBA: 
Hbal_2819
NAR: 
Saro_3511
NPP: 
PP1Y_AT15701 PP1Y_AT31588 PP1Y_AT32745
SAL: 
Sala_3044
SWI: 
Swit_0742 Swit_3520
SPHM: 
G432_01985
SJP: 
SJA_C1-11870(mhpD)
SCH: 
Sphch_0679 Sphch_3082
GDI: 
GDI_2732(mhpD)
ALI: 
AZOLI_p50268
BCA: 
BCE_2155
BCF: 
bcf_10205
BCER: 
BCK_24230
BTL: 
BALH_1842(pheD)
GTN: 
GTNG_3153(nbaH)
GTH: 
Geoth_1677
GYA: 
GYMC52_1424
GCT: 
GC56T3_2057
GMC: 
GY4MC1_1594
GGH: 
GHH_c14820
SIV: 
SSIL_0063
DKU: 
Desku_0615
DOR: 
Desor_0611
MTU: 
Rv3536c(hsaE)
MTV: 
RVBD_3536c
MTC: 
MT3640(mhpD)
MRA: 
MRA_3575(mhpD)
MTF: 
TBFG_13569
MTB: 
TBMG_03576
MTK: 
TBSG_03602
MTZ: 
TBXG_003551
MTG: 
MRGA327_21845
MTI: 
MRGA423_22340
MTE: 
CCDC5079_3277
MTL: 
CCDC5180_3229
MTO: 
MTCTRI2_3600
MTD: 
UDA_3536c
MTN: 
ERDMAN_3880
MTJ: 
J112_19040
MTUB: 
MT7199_3598(hasE)
MBO: 
Mb3566c
MBB: 
BCG_3600c
MBT: 
JTY_3601
MBM: 
BCGMEX_3598c
MBK: 
K60_036740
MAF: 
MAF_35480
MCE: 
MCAN_35471
MCQ: 
BN44_110028(mhpD)
MCV: 
BN43_90034(mhpD)
MCX: 
BN42_90031(mhpD)
MCZ: 
BN45_100031(mhpD)
MPA: 
MAP0531
MAV: 
MAV_0625
MIT: 
OCO_05350
MIR: 
OCQ_05500
MIA: 
OCU_05390 OCU_15220
MID: 
MIP_00989
MSA: 
Mycsm_01983
MUL: 
MUL_4097
MMV: 
MYCMA_2427(todJ)
MMI: 
MMAR_5023
MRH: 
MycrhN_3139
MMM: 
W7S_02620
MLI: 
MULP_05275
CDR: 
CDHC03_1947(mhpD)
NFA: 
nfa30420 nfa33180 nfa4650
RHA: 
RHA1_ro00517 RHA1_ro03881 RHA1_ro08085(bphE3) RHA1_ro10117(bphE4)
RER: 
RER_57560
ROP: 
ROP_pROB02-02260
REQ: 
REQ_42080
SCO: 
SCP1.299 SCP1.55c
SCB: 
SCAB_2091(mhpD)
SVL: 
Strvi_3230
SBH: 
SBI_01533
SDV: 
BN159_1390(mhpD)
KSK: 
KSE_23730
SRO: 
Sros_9115
FRE: 
Franean1_2884
FRI: 
FraEuI1c_4106
FSY: 
FsymDg_2036
AMN: 
RAM_44255
AMM: 
AMES_8492
AMS: 
AMIS_19120
AYM: 
YM304_39990
TPI: 
TREPR_1322
CAP: 
CLDAP_40920
TTJ: 
TTHB239
TTL: 
TtJL18_2421
TSC: 
TSC_c11610
THC: 
TCCBUS3UF1_13020
TOS: 
Theos_2469
 » show all
Taxonomy
Reference
1  [PMID:7287632]
  Authors
Kunz DA, Ribbons DW, Chapman PJ.
  Title
Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid.
  Journal
J. Bacteriol. 148 (1981) 72-82.
  Organism
Pseudomonas putida
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
64427-80-1
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