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Entry
EC 4.2.1.84                 Enzyme                                 

Name
nitrile hydratase;
nitrilase (ambiguous);
3-cyanopyridine hydratase;
NHase;
L-NHase;
H-NHase;
acrylonitrile hydratase;
aliphatic nitrile hydratase;
nitrile hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
aliphatic-amide hydro-lyase (nitrile-forming)
Reaction(IUBMB)
an aliphatic amide = a nitrile + H2O [RN:R02826]
Reaction(KEGG)
Substrate
aliphatic amide [CPD:C02244]
Product
nitrile [CPD:C00726];
H2O [CPD:C00001]
Comment
Acts on short-chain aliphatic nitriles, converting them into the corresponding amides. Does not act on these amides or on aromatic nitriles. cf. EC 3.5.5.1 nitrilase.
History
EC 4.2.1.84 created 1989
Pathway
Fluorobenzoate degradation
Tryptophan metabolism
Aminobenzoate degradation
Styrene degradation
Microbial metabolism in diverse environments
Orthology
K01721  
nitrile hydratase
Genes
KPE: 
KPK_2672(nthA) KPK_2673(nthB)
KVA: 
KOX: 
KOE: 
KOY: 
SRY: 
PVA: 
PAO: 
PPF: 
PPB: 
PPI: 
PPUU: 
PFS: 
PSK: 
ACI: 
ACIAD1615(nthB) ACIAD1616(nthA)
RSL: 
BCN: 
BCH: 
BCM: 
BAM: 
BAC: 
BPY: 
BGD: 
BYI: 
BPX: 
BUO: 
BPT: 
Bpet1415(nthB) Bpet1416(nthA)
AAA: 
VAP: 
VPE: 
VPD: 
HSE: 
MLO: 
MCI: 
MOP: 
MAM: 
SME: 
SMc01423(nthB) SMc01424(nthA)
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMD: 
RHI: 
SFH: 
SFD: 
EAD: 
OV14_3491(nthB) OV14_3492(nthA)
ARA: 
Arad_2889(nthB) Arad_2890(nthA)
RET: 
REC: 
REL: 
RLE: 
RLT: 
RLG: 
RLB: 
RLU: 
RTR: 
RIR: 
RHL: 
NGL: 
BJA: 
bll4497(nthB) bll4498(nthA)
BJU: 
BRA: 
BRADO3845(nthA) BRADO3846(nthB)
BBT: 
BBta_4084(nthB) BBta_4085(nthA)
BRS: 
S23_36770(nthA) S23_36780(nthB)
AOL: 
RPA: 
RPA2805(nthA) RPA2806(nthB)
RPB: 
RPC: 
RPD: 
RPT: 
RPX: 
AZC: 
MRD: 
MET: 
MPO: 
MNO: 
MSL: 
RVA: 
SIL: 
SPO1314(nthA) SPO1315(nthB)
SIT: 
RDE: 
RD1_1908(nthA) RD1_1909(nthB)
RLI: 
DSH: 
Dshi_1849(nthA)
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
LMD: 
PTP: 
ACR: 
AMV: 
ABS: 
TMO: 
PGV: 
APB: 
MSM: 
MSG: 
MSA: 
MVA: 
MGI: 
MSP: 
MJL: 
MRH: 
MNE: 
RHA: 
RER: 
RER_59240(nha1) RER_59250(nha2)
REY: 
ROA: 
GPO: 
SVL: 
SHY: 
SHO: 
SRC: 
SALU: 
AAU: 
GOB: 
MMAR: 
AMQ: 
PDX: 
RXY: 
SYP: 
AMR: 
AM1_1194(nthA) AM1_1195(nthB)
GLP: 
CMP: 
PSEU: 
HAH: 
 » show all
Taxonomy
Reference
1
  Authors
Asano, Y., Fujishiro, K., Tani, Y. and Yamada, H.
  Title
Microbial degradation of nitrile compounds. 5. Aliphatic nitrile hydratase from Arthrobacter sp J-1. Purification and characterization.
  Journal
Agric. Biol. Chem. 46 (1982) 1165-1174.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
82391-37-5

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