KEGG   ENZYME: 4.2.2.8Help
Entry
EC 4.2.2.8                  Enzyme                                 

Name
heparin-sulfate lyase;
heparin-sulfate eliminase;
heparitin-sulfate lyase;
heparitinase I;
heparitinase II
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
heparin-sulfate lyase
Reaction(IUBMB)
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Comment
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
History
EC 4.2.2.8 created 1972
Orthology
K19051  
heparin/heparan-sulfate lyase
K19052  
heparan-sulfate lyase
Genes
BTH: 
BHL: 
BXY: 
ASH: 
NKO: 
PHE: 
PSN: 
COC: 
Taxonomy
Reference
1  [PMID:5484472]
  Authors
Hovingh P, Linker A.
  Title
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.
  Journal
J. Biol. Chem. 245 (1970) 6170-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37290-86-1

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