KEGG   ENZYME: 4.2.2.8Help
Entry
EC 4.2.2.8                  Enzyme                                 

Name
heparin-sulfate lyase;
heparin-sulfate eliminase;
heparitin-sulfate lyase;
heparitinase I;
heparitinase II
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
heparin-sulfate lyase
Reaction(IUBMB)
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Comment
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
History
EC 4.2.2.8 created 1972
Orthology
K19051  heparin/heparan-sulfate lyase
K19052  heparan-sulfate lyase
Genes
BTH: BT_4657 BT_4662
BTHO: Btheta7330_03330(hepC_1)
BHL: Bache_1616
BXY: BXY_37640 BXY_37690
BOA: Bovatus_04868(hepC_3)
ASH: AL1_01210 AL1_01260
NKO: Niako_3778
PHE: Phep_2408 Phep_3797
PSN: Pedsa_0684 Pedsa_1814 Pedsa_1818
COC: Coch_0606
Taxonomy
Reference
1  [PMID:5484472]
  Authors
Hovingh P, Linker A.
  Title
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.
  Journal
J. Biol. Chem. 245 (1970) 6170-5.
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.8
IUBMB Enzyme Nomenclature: 4.2.2.8
ExPASy - ENZYME nomenclature database: 4.2.2.8
BRENDA, the Enzyme Database: 4.2.2.8
CAS: 37290-86-1

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